p63 expression in normal human epidermis and epidermal appendages and their tumors

Tsujita-Kyutoku, Miki; Kiuchi, Katsuji; Danbara, Naoyuki; Yuri, Takashi; Senzaki, Hideto; Tsubura, Airo

doi:10.1034/j.1600-0560.2003.300102.x

Cited by 84 publications

(110 citation statements)

References 27 publications

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“…Kaufmann et al The expression of p63 in normal human epidermis, cutaneous appendages and skin carcinomas has been recently assessed. [16][17][18] p63 seems to play a major role in ectodermal development, in the maintenance of the basal cell population of stratified epithelia, and also in the terminal differentiation of epithelia. [6][7][8] In vitro studies, using transformed human keratinocytes, have shown that p63 is a nuclear transcription factor that triggers keratinocyte differentiation and is downregulated in terminally differentiated cells.…”

Section: Discussionmentioning

confidence: 99%

“…10,12,14 The expression of p63 in normal human epidermis, cutaneous appendages and skin carcinomas has been recently assessed. 16,17 In these studies, p63 was detected in the epidermal and adnexal basal/ myoepithelial cells and it has been suggested that p63 might be used as a diagnostic marker for epidermal or adnexal tumors in the skin. [16][17][18] Cutaneous metastases may be the initial manifestation of some neoplasms, including adenocarcinomas.…”

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confidence: 99%

“…16,17 In these studies, p63 was detected in the epidermal and adnexal basal/ myoepithelial cells and it has been suggested that p63 might be used as a diagnostic marker for epidermal or adnexal tumors in the skin. [16][17][18] Cutaneous metastases may be the initial manifestation of some neoplasms, including adenocarcinomas. The distinction between such metastases and primary cutaneous neoplasms, especially adnexal tumors, on histologic grounds alone, may be difficult.…”

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Expression of p63 in primary cutaneous adnexal neoplasms and adenocarcinoma metastatic to the skin

2005

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p63, a recently identified homologue of the p53 gene, has been reported to be essential in the development of epithelia and is mainly expressed by basal and myoepithelial cells. The purpose of this study was to investigate the pattern of p63 expression in cutaneous adnexal neoplasms and to assess its possible value in the differential diagnosis of primary cutaneous neoplasms vs adenocarcinomas metastatic to the skin. Immunohistochemical analysis for p63 was performed on formalin-fixed, paraffin-embedded archival tissue from 20 benign adnexal tumors, 10 malignant adnexal tumors and 14 adenocarcinomas metastatic to the skin. The expression of p63 was evaluated in epidermal cells, skin appendages and metastatic tumor cells. p63 was consistently expressed in the basal and suprabasal cells of epidermis and cutaneous appendages, including the basal/myoepithelial cells of sweat glands. Out of 20 benign adnexal tumors, 13 (65%) showed strong (score 3) p63 expression; the remaining seven (35%) cases had score 2. All primary cutaneous carcinomas, including adenocarcinomas, expressed p63. In contrast, none of the metastatic adenocarcinomas to the skin was positive for p63 (Po0.001). Based on our findings, analysis of p63 expression may help in the differential diagnosis of primary vs metastatic cutaneous adenocarcinomas.

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Expression of p63 in primary cutaneous adnexal neoplasms and adenocarcinoma metastatic to the skin

2005

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“…p63 is a diagnostic marker of basal/progenitor cells of the adnexal tumors. p63 might block the apoptosis inducing activity of p53 and thus could maintain the proliferative capacity of basal/progenitor cells 15,16 . P63 expression was also reported in trichilemmal carcinoma 15 .…”

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confidence: 99%

A Case of Trichilemmal Carcinoma Treated with Mohs Micrographic Surgery

et al. 2008

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Trichilemmal carcinoma is a cutaneous adnexal tumor originating from the outer root sheath of hair follicle, and it was first described by Headington in 1976. Clinically, it usually occurs as an asymptomatic solitary papule, nodule or mass on the face or scalp. This neoplasm is a malignant counterpart of trichilemmoma, and it has been reported in the literature as trichilemmal carcinoma, tricholemmal carcinoma, malignant trichilemmoma, and tricholemmocarcinoma. Although histologically, trichilemmal carcinoma frequently has maliganant features, it has a relatively benign clinical behavior. We think Mohs micrographic surgery is a useful treatment modality in trichilemmal carcinoma because the final skin defect is smaller than a wide excision. We report a case of primary trichilemmal carcinoma which had developed on the face, treated with Mohs micrographic surgery. The lesion enlarged slowly with bleeding tendency on the surface (Fig. 1). He had a past history of liver cirrhosis with elevated liver enzymes and serologic markers of hepatitis B virus infection. Abdomen computerized tomography and ultrasonograghy showed hepatosplenomegaly without any evidence of regional lymph node metastasis. We could not find any abnormal findings on the head and neck computerized tomography either.An incisional biopsy was done under the impression of squamous cell carcinoma. Histopathologically, we could observe a relatively well-circumscribed tumor, which was connected with the

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“…Possui também importante papel no desenvolvimento e na proliferação epitelial de diversas estruturas, como, as crânio-faciais (TSUJITA-KYUTOKU et al, 2003).…”

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Análise imunoistoquímica das proteínas maspin, p63 e bcl2 em tumor odontogênico queratocístico, cisto dentígero e ameloblastoma

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p63 expression in normal human epidermis and epidermal appendages and their tumors

Abstract: p63 expression may be a marker of basal/progenitor cells in tumors of epidermis and epidermal appendages, and may be a diagnostic marker of these tumors.

Cited by 84 publications

References 27 publications

Expression of p63 in primary cutaneous adnexal neoplasms and adenocarcinoma metastatic to the skin

Expression of p63 in primary cutaneous adnexal neoplasms and adenocarcinoma metastatic to the skin

A Case of Trichilemmal Carcinoma Treated with Mohs Micrographic Surgery

Análise imunoistoquímica das proteínas maspin, p63 e bcl2 em tumor odontogênico queratocístico, cisto dentígero e ameloblastoma

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