“…Our data, in addition to other studies (Jin et al , ), indicate that p62 interacts with ubiquitinated caspase‐8 and facilitates its aggregation and full activation. Since both p62 and TP53INP2 are involved in differentiation (Linares et al , ; McManus & Roux, ; Li et al , ; Sugiyama et al , ), apoptosis (Jin et al , ; Moscat & Diaz‐Meco, ; Bhattacharya et al , ), nuclear hormone receptor signaling (Baumgartner et al , ; Duran et al , ), diabetes (Sala et al , ; Kruse et al , ; Long et al , ), and autophagy (Pankiv et al , ; Moscat & Diaz‐Meco, ; Nowak et al , ; Mauvezin et al , ; Sancho et al , ), further studies are needed to unravel how they interplay/overlap in these pathways. Along the same line, TRAF6 has been implicated in multiple signaling pathways, such as autophagy, development, and immunity (Linares et al , ; Walsh et al , ).…”