P62 Management of endometrial cancer in elderly patients identifying patients who may benefit from a curative treatment

Benito, Virginia; Lubrano, Amina; Andújar, MB Sánchez; Mori, Marta; Federíco, M.

doi:10.1136/ijgc-2019-esgo.124

Cited by 9 publications

(19 citation statements)

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“…Indeed, older patients with OC show an impaired survival prognosis compared to younger patients [ 2 , 11 ]. For elderly patients with endometrial cancer (EC), cancer specific survival rate was lower among the elderly and very elderly women than among their younger counterparts [ 5 , 13 , 14 ]. With the growing number of older endometrial and ovarian cancer survivors, data on long-term health-related quality of life (HRQoL) became an important issue in the management of older patients.…”

Section: Introductionmentioning

confidence: 99%

Long-term quality of life and sexual function of elderly people with endometrial or ovarian cancer

Kamga

Bengrine-Lefèvre

Quipourt

et al. 2021

Health Qual Life Outcomes

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Background With the growing number of older endometrial cancer (EC) and ovarian cancer (OC) survivors, data on long-term health-related quality of life (HRQoL) became an important issue in the management of older patients. So, the aim of this study was to describe and compare according to age long-term HRQoL, sexual function, and social deprivation of adults with either EC or OC. Methods A cross-sectional study was set up using data from the Côte d’Or gynecological cancer registry. A series of questionnaires assessing HRQoL (SF-12), sexual function (FSFI), anxiety/depression (HADS), social support (SSQ6) and deprivation (EPICES) were offered to women with EC or OC diagnosed between 2006 and 2013. HRQoL, sexual function, anxiety/depression, social support and deprivation scores were generated and compared according to age (< 70 years and ≥ 70 years). Results A total of 145 women with EC (N = 103) and OC (N = 42) participated in this study. Fifty-six percent and 38% of EC and OC survivors respectively were aged 70 and over. Treatment did not differ according to age either in OC or EC. The deprivation level did not differ between older and younger survivors with OC while older survivors with EC were more precarious. The physical HRQoL was more altered in older EC survivors. This deterioration concerned only physical functioning (MD = 24, p = 0.012) for OC survivors while it concerned physical functioning (MD = 30, p < 0.0001), role physical (MD = 22, p = 0.001) and bodily pain (MD = 21, p = 0.001) for EC survivors. Global health (MD = 11, p = 0.011) and role emotional (MD = 12, p = 0.018) were also deteriorated in elderly EC survivors. Sexual function was deteriorated regardless of age and cancer location with a more pronounced deterioration in elderly EC survivors for desire (p = 0.005), arousal (p = 0.015) and orgasm (p = 0.007). Social support, anxiety and depression were not affected by age regardless of location. Conclusion An average 6 years after diagnosis, the impact of cancer on HRQoL is greatest in elderly survivors with either EC or OC.

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Section: Introductionmentioning

confidence: 99%

Long-term quality of life and sexual function of elderly people with endometrial or ovarian cancer

Kamga

Bengrine-Lefèvre

Quipourt

et al. 2021

Health Qual Life Outcomes

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“…Endometrial cancer is common cancer, and its incidence is increasing globally [1][2][3][4][5][6][7][8]. The number of elderly patients with endometrial cancer has gradually increased as well [1,2].…”

Section: Introductionmentioning

confidence: 99%

“…The standard therapy for endometrial cancer includes comprehensive surgical operation and adjuvant chemotherapy. Generally, elderly patients are less likely to be offered operative therapy, lymph node dissection, and adjuvant chemotherapy [2][3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

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Clinical Treatment of Elderly Patients with Endometrial Cancer

Hashiguchi¹

2021

JGWH

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characteristics do not appear to be able to entirely indicate the unfavorable prognosis of elderly patients with endometrial cancer [2,6]. In this study, we investigated clinical treatment and outcomes of elderly patients with endometrial cancer. MethodsThis retrospective study was approved by the Institutional Review Board. Available clinical records from January 2014 to December 2019 were reviewed, and the patients were divided two group: elderly patients (age: 75 years or older than 75) and younger patients (age: younger than 75). We examined clinical treatment and outcomes of elderly patients.

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“…prognosis owing to the significant advances in diagnostic and therapeutic modalities [3]. Chemotherapy is the mainstay treatment of endometrial carcinoma.…”

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confidence: 99%

Neutropenic enterocolitis-induced sepsis and disseminated intravascular coagulation after chemotherapy: a case report

et al. 2021

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Background Neutropenic enterocolitis (NE) is a potentially life-threatening disease that primarily occurs in cancer patients treated with chemotherapy. NE has substantial morbidity and mortality, and its incidence has increased with the widespread use of chemotherapeutic agents such as taxanes, gemcitabine, and leucovorin in patients with lung, breast, gastric, and ovarian cancers. Sometimes NE can be a possible cause of death. Although, conservative approaches are often successful, there are currently no standardized treatment guidelines for NE and it is unclear when such strategies should be implemented. Therefore, we present this report to provide a greater insight into the possible treatment of NE. Case presentation We report the case of a 72-year-old woman with endometrial cancer who was undergoing treatment for hypertension, obesity and diabetes mellitus. The patient initially developed paralytic ileus on the 6th postoperative day (POD) after surgery for endometrial serous carcinoma. Complete recovery was achieved after 4 days of fasting and fluid replacement therapy. On the 27th POD, she received the first cycle of combination chemotherapy consisting of paclitaxel and carboplatin. On day 5 of chemotherapy, she developed the systemic inflammatory response syndrome including febrile neutropenia and sepsis. She then developed disseminated intravascular coagulation (DIC) and septic shock. The patient was subsequently moved to the intensive care unit (ICU). Despite initiating the standard treatment for septic shock and DIC, her overall status worsened. It was assumed that gut distention had led to bowel damage, subsequently leading to bacterial translocation. Thus, she developed NE with severe DIC and septic shock. We decided to reduce the intestinal pressure using an ileus tube to suction the additional air and fluid, even though doing so had a risk of worsening her general condition. The inflammatory reaction subsided, and her general condition improved. The patient recovered after 18 days in the ICU and was discharged alive. Conclusions Herein, we describe a patient with suspected chemotherapy-associated NE. Our observations suggest that postoperative ileus may be one of the possible causes of NE. Patients who experience postoperative ileus must be carefully monitored while undergoing chemotherapy.

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P62 Management of endometrial cancer in elderly patients identifying patients who may benefit from a curative treatment

Cited by 9 publications

References 0 publications

Long-term quality of life and sexual function of elderly people with endometrial or ovarian cancer

Long-term quality of life and sexual function of elderly people with endometrial or ovarian cancer

Clinical Treatment of Elderly Patients with Endometrial Cancer

Neutropenic enterocolitis-induced sepsis and disseminated intravascular coagulation after chemotherapy: a case report

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