P601Cardio-protective effects of exercise are abolished in pressure-overload following aortic constriction by increased eNOS uncoupling and oxidative stress

Octavia, Yanti; Deel, ED Van; Waard, MC de; Moens, AL; Duncker, DJ

doi:10.1093/cvr/cvu098.30

Cardiovasc Res

2014

DOI: 10.1093/cvr/cvu098.30

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P601Cardio-protective effects of exercise are abolished in pressure-overload following aortic constriction by increased eNOS uncoupling and oxidative stress

Yanti Octavia

ED Van Deel²,

MC de Waard³

et al.

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2018

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Hypoperfusion Induced by Preconditioning Treadmill Training in Hyper-Early Reperfusion After Cerebral Ischemia: A Laser Speckle Imaging Study

Yang

et al. 2018

IEEE Trans. Biomed. Eng.

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Exercise preconditioning induces neuroprotective effects during cerebral ischemia and reperfusion, which involves the recovery of cerebral blood flow (CBF). Mechanisms underlying the neuroprotective effects of re-established CBF following ischemia and reperfusion are unclear. The present study investigated CBF in hyper-early stage of reperfusion by laser speckle contrast imaging, a full-field high-resolution optical imaging technique. Rats with or without treadmill training were subjected to middle cerebral artery occlusion followed by reperfusion. CBF in arteries, veins, and capillaries in hyper-early stage of reperfusion (1, 2, and 3 h after reperfusion) and in subacute stage (24 h after reperfusion) were measured. Neurological scoring and 2,3,5-triphenyltetrazolium chloride staining were further applied to determine the neuroprotective effects of exercise preconditioning. In hyper-early stage of reperfusion, CBF in the rats with exercise preconditioning was reduced significantly in arteries and veins, respectively, compared to rats with no exercise preconditioning. Capillary CBF remained stable in the hyper-early stage of reperfusion, though it increased significantly 24 h after reperfusion in the rats with exercise preconditioning. As a neuroprotective strategy, exercise preconditioning reduced the blood perfusion of arteries and veins in the hyper-early stage of reperfusion, which indicated intervention-induced neuroprotective hypoperfusion after reperfusion onset.

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Hypoperfusion Induced by Preconditioning Treadmill Training in Hyper-Early Reperfusion After Cerebral Ischemia: A Laser Speckle Imaging Study

Yang

et al. 2018

IEEE Trans. Biomed. Eng.

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P601Cardio-protective effects of exercise are abolished in pressure-overload following aortic constriction by increased eNOS uncoupling and oxidative stress

Cited by 1 publication

References 0 publications

Hypoperfusion Induced by Preconditioning Treadmill Training in Hyper-Early Reperfusion After Cerebral Ischemia: A Laser Speckle Imaging Study

Hypoperfusion Induced by Preconditioning Treadmill Training in Hyper-Early Reperfusion After Cerebral Ischemia: A Laser Speckle Imaging Study

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