Abstract:The novel tyrosine kinase inhibitor nilotinib is equipotent with imatinib and does not induce apoptosis in CML stem cells Chronic myeloid leukaemia (CML) is a myeloproliferative disorder of stem cell origin characterised by a shortened 'Philadelphia' (Ph + ) chromosome 22. A novel oncoprotein BcrAbl is translated from the fusion oncogene, bcrabl, that arises from the t 9;22 reciprocal translocation. BcrAbl is a constitutively active tyrosine kinase that upregulates diverse intracellular signal transduction pat… Show more
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