P5809Hypoxic-hyperoxic preconditioning: a novel technique for myocardial protection against ischemia-reperfusion injury in coronary surgery

Mandel, Irina A.; Михеев, С. Л.; Podoksenov, Yu. K.; Svirko, Yulia S.; Suhodolo, Irina V.; Шипулин, В. М.

doi:10.1093/eurheartj/ehx493.p5809

Cited by 4 publications

(5 citation statements)

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“…Sample size calculation was carried out for the study with 130 patients randomized in the proportion of 1:1. Due to the lack of a unified protocol, we developed our protocol of preconditioning, which allows us to simulate the phenomenon of hypoxic-hyperoxic preconditioning in animals and humans [46,47]. The sample size calculation was based on our previous results [46].…”

Section: Discussionmentioning

confidence: 99%

“…Due to the lack of a unified protocol, we developed our protocol of preconditioning, which allows us to simulate the phenomenon of hypoxic-hyperoxic preconditioning in animals and humans [46,47]. The sample size calculation was based on our previous results [46]. The proportion of participants treated with HHP that could meet the criteria for an ischemia-reperfusion injury is estimated at 25% (with 95 % CIs), and the proportion of participants not treated with HHP could be 42%.…”

Section: Discussionmentioning

confidence: 99%

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Endothelial Function and Hypoxic-Hyperoxic Preconditioning in Coronary Surgery with a Cardiopulmonary Bypass: Randomized Clinical Trial

Mandel¹,

Podoksenov²,

Михеев³

et al. 2023

Preprint

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Background: The hypothesis is that a hypoxic-hyperoxic preconditioning (HHP) is associated with a protective effect on myocardial function by reducing endothelial damage and a beneficial effect on postoperative outcome in patients undergoing cardiac surgery with cardiopulmonary bypass (CPB). Methods: Patients (n=120) were randomly assigned to an HHP and a control group. A safe inhaled oxygen fraction for the hypoxic preconditioning phase (10-14% oxygen for 10 minutes) was determined by measuring the anaerobic threshold. At hyperoxic phase, 75-80% oxygen fraction was used during 30 minutes. Results: The cumulative frequency of postoperative complications was 14 (23.3%) in the HHP vs 23 (41.1%), p=0.041. The nitrate decreased after surgery by up to 20% in the HHP group and up to 38% in the control group. Endothelin-1 and nitric oxide metabolites were stable in HHP but remained low more than 24 h in control group. The endothelial damage markers appeared to be predictors of postoperative complications. Conclusion: The HHP with individual parameters based on the anaerobic threshold is a safe procedure, it can reduce the frequency of postoperative complications. The endothelial damage markers appeared to be predictors of postoperative complications.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Endothelial Function and Hypoxic-Hyperoxic Preconditioning in Coronary Surgery with a Cardiopulmonary Bypass: Randomized Clinical Trial

Mandel¹,

Podoksenov²,

Михеев³

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…Sample size calculation was provided for the study with 130 patients randomized into the two equal groups. Due to the lack of a unified protocol, we developed our protocol of preconditioning, which allows us to simulate the phenomenon of hypoxic–hyperoxic preconditioning in animals and humans [ 24 , 25 ]. The sample size calculation was based on our previous results [ 24 ].…”

Section: Methodsmentioning

confidence: 99%

“…Due to the lack of a unified protocol, we developed our protocol of preconditioning, which allows us to simulate the phenomenon of hypoxic–hyperoxic preconditioning in animals and humans [ 24 , 25 ]. The sample size calculation was based on our previous results [ 24 ]. The proportion of patients treated with HHP that could meet the criteria for an IRI is estimated at 25% (with 95% confidence interval), and the proportion of control patients could be 42%.…”

Section: Methodsmentioning

confidence: 99%

Endothelial Function and Hypoxic–Hyperoxic Preconditioning in Coronary Surgery with a Cardiopulmonary Bypass: Randomized Clinical Trial

et al. 2023

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A hypoxic–hyperoxic preconditioning (HHP) may be associated with cardioprotection by reducing endothelial damage and a beneficial effect on postoperative outcome in patients undergoing cardiac surgery with cardiopulmonary bypass (CPB). Patients (n = 120) were randomly assigned to an HHP and a control group. A safe, inhaled oxygen fraction for the hypoxic preconditioning phase (10–14% oxygen for 10 min) was determined by measuring the anaerobic threshold. At the hyperoxic phase, a 75–80% oxygen fraction was used for 30 min. The cumulative frequency of postoperative complications was 14 (23.3%) in the HHP vs. 23 (41.1%), p = 0.041. The nitrate decreased after surgery by up to 20% in the HHP group and up to 38% in the control group. Endothelin-1 and nitric oxide metabolites were stable in HHP but remained low for more than 24 h in the control group. The endothelial damage markers appeared to be predictors of postoperative complications. The HHP with individual parameters based on the anaerobic threshold is a safe procedure, and it can reduce the frequency of postoperative complications. The endothelial damage markers appeared to be predictors of postoperative complications.

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“…In two trials identified in our database search, details of the study intervention were reported with insufficient depth to be evaluated as part of our review and were not included. 24,25 The authors were contacted for clarification, but we did not receive a response. The 12 included RCTs were published between 1991 and 2016 (Table 1).…”

Section: Study Characteristicsmentioning

confidence: 99%

Répercussions de l’hyperoxie sur les résultats après une chirurgie cardiaque : revue systématique et synthèse narrative

Heinrichs

Lodewyks

Neilson

et al. 2018

Can J Anesth/J Can Anesth

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P5809Hypoxic-hyperoxic preconditioning: a novel technique for myocardial protection against ischemia-reperfusion injury in coronary surgery

Cited by 4 publications

References 0 publications

Endothelial Function and Hypoxic-Hyperoxic Preconditioning in Coronary Surgery with a Cardiopulmonary Bypass: Randomized Clinical Trial

Endothelial Function and Hypoxic-Hyperoxic Preconditioning in Coronary Surgery with a Cardiopulmonary Bypass: Randomized Clinical Trial

Endothelial Function and Hypoxic–Hyperoxic Preconditioning in Coronary Surgery with a Cardiopulmonary Bypass: Randomized Clinical Trial

Répercussions de l’hyperoxie sur les résultats après une chirurgie cardiaque : revue systématique et synthèse narrative

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