P57 SIGNIFICANCE OF SERUM miR-10b-3p IN PREDICTING PRESENCE OF MICROVASCULAR INVASION OF HEPATOCELLULAR CARCINOMA (HCC)

Yoon, Eungjun; Yeon, J.E.; Ko, Eungil; Je, Janik; Yoo, Yang Jae; Kang, Kwi Young; Kang, Seung-Hee; Kim, H.R.; Lee, H.J.; Suh, S.J.; Kim, J.H.; Seo, Y.S.; Yim, H.J.; Byun, K.S.

doi:10.1016/s0168-8278(14)60220-8

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“…Additionally, perinatally infected children may also have poorer fat absorption in the gastrointestinal tract than uninfected children which can affect the child FA profile [18]. Long term effects of childhood dyslipidemia include increased risk of obesity, diabetes, and hypertension [19]. Hence, ART therapies are administered to pregnant HIV positive mothers to prevent child HIV infection and its related effects.…”

Section: Introductionmentioning

confidence: 99%

Serum n-6 Fatty Acids are Positively Associated with Growth in 6-to-10-Year Old Ugandan Children Regardless of HIV Status—A Cross-Sectional Study

et al. 2019

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Fatty acids (FAs) are crucial in child growth and development. In Uganda, antiretroviral therapy (ART) has drastically reduced perinatal human immunodeficiency virus (HIV) infection of infants, however, the interplay of FAs, ART, and HIV in relation to child growth is not well understood. To investigate this, serum was collected from 240 children between 6–10 years old in Uganda and analyzed for FAs using gas-chromatography mass-spectrometry. HIV status and anthropometric measurements were taken, and relationships with FAs were assessed. No significant differences in growth parameters or serum FAs were found between HIV uninfected children with and without exposure to ART. HIV positive children had significantly lower height-for-age-z-scores (HAZ) than uninfected children (p < 0.001). HIV-positive children had higher arachidonic acid than uninfected children (p = 0.003). Total omega-6 FAs were significantly associated with HAZ regardless of HIV status (p = 0.035). Mean total omega-3 FAs (2.90%) were low in this population compared to other cohorts in Africa. These results provide reference serum FA values for 6–10-year-old children in Uganda and may be used to inform lipid supplementation programs to promote child growth. Future studies should investigate the relationships between child growth trajectories in relation to HIV status and serum FAs.

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Section: Introductionmentioning

confidence: 99%