p57 kip2 immunohistochemistry: ancillary technique in hydatidiform moles diagnosis

Fernández, Jessica; Cortés, Rafael González; Salazar, Aleydah; Pulido, Aníbal; Dabed, Pablo; García, Victoria

doi:10.1186/1753-6561-7-s2-p33

Cited by 2 publications

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“…It is the protein product of the CDKN1C gene, located on chromosome 11p15.5 and is paternally imprinted and maternally expressed. Thus, since the complete molar pregnancy is missing genetic material from the mother, it is not expected to show CDKN1C gene expression [ 3 , 8 - 10 , 19 ]. On the other hand, the cases of hydropic abortions (biparental diploidy) and partial molar pregnancy (diandric triploidy) are expected to show p57 positivity in the cytotrophoblasts and villous stromal cells.…”

Section: Discussionmentioning

confidence: 99%

Molecular and immunohistochemical characteristics of complete hydatidiform moles

Kubelka-Sabit

I²,

Jasar

et al. 2017

Balkan Journal of Medical Genetics

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Molar pregnancy is a gestational trophoblastic disease that belongs to the category of precancerous lesions. On the other end of the spectrum are gestational trophoblastic neoplasms such as invasive mole, choriocarcinoma, placental site trophoblastic tumor and epithelioid trophoblastic tumor, which are considered malignant tumors. Based on defined histopathological criteria, molar pregnancy is divided into partial and complete hydatidiform mole. Especially in the case of early complete mole, the diagnosis can be quite challenging and often necessitates additional molecular or immunohistochemical methods. The aim of this study was to assess the importance of additional molecular and immunohistochemical methods to accurately diagnose complete hydatidiform mole and to stress the importance of correct diagnosis and close follow-up of these patients. A total of 367 consecutive cases of spontaneous abortion were analyzed in a 3-year period. Eight cases with histopathological diagnosis of complete molar pregnancy were selected for further analysis. Apart from standard microscopic analysis, additional molecular and immunohistochemical analyses were performed in all eight cases. Most of the histopathological characteristics of complete molar pregnancy were present in all cases, together with complete absence of positivity for the p57 immunohistochemical marker in the cytotrophoblasts and villous stromal cells. The molecular analysis revealed androgenetic diploidy in seven cases and biparental diploidy in one case with more than three consecutive complete molar pregnancies. Additional immunohistochemical and molecular methods can considerably aid in the correct diagnosis of molar pregnancy.

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Section: Discussionmentioning

confidence: 99%

Molecular and immunohistochemical characteristics of complete hydatidiform moles

Kubelka-Sabit

I²,

Jasar

et al. 2017

Balkan Journal of Medical Genetics

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show abstract

“…A complementary method to pathology interpretation is immunohistechemistry (IHC). 6 One of the advantages of this method is the ability to apply it retrospectively to sections of routinely formalin-fixed and paraffin embedded (FFPE) tissue. Another advantage is that there is no need for expensive or sophisticated equipment.…”

Section: Methodsmentioning

confidence: 99%

P57Kip2 immunostaining, a diagnostic marker in differentiating complete hydatidiform mole from its mimics

Ismael

2016

ZJMS

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p57 kip2 immunohistochemistry: ancillary technique in hydatidiform moles diagnosis

Cited by 2 publications

References 0 publications

Molecular and immunohistochemical characteristics of complete hydatidiform moles

Molecular and immunohistochemical characteristics of complete hydatidiform moles

P57Kip2 immunostaining, a diagnostic marker in differentiating complete hydatidiform mole from its mimics

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