“…16, 19-21, 23, 24, 26-29 Rates of DR in biologic naïve patients (Fig. 4) was 36.4% (95% CI: 12.6-69.4%) in 86/229 patients at eight weeks in four studies, 20, 23, 24, 29 39.1% (95% CI: 10.4-78%) in 62/155 patients at 6 months in four studies, 19,21,24,28 47.2% (95% CI: 34.5-60.4%) in 129/284 patients at one year in six studies, 16,19,21,23,24,27 and 46.7% (95% CI: 23.9-71%) in 52/129 patients at two years in three studies. 19,21,26 Funnel plot and Egger's tests did not demonstrate publication bias except for 2 years (Egger's t-value = 8.607, p = 0.037).…”