p53 target miR-29c-3p suppresses colon cancer cell invasion and migration through inhibition of PHLDB2

Chen, Geng; Zhou, Tong; Yang, Li; Yu, Ziyou; Sun, Liankun

doi:10.1016/j.bbrc.2017.04.023

Cited by 56 publications

(49 citation statements)

References 22 publications

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“…33 In addition, it has been reported that miR-29c is significantly down-regulated in colon cancer. 34 In this study, we also found that miR-29c-3p…”

Section: Discussionsupporting

confidence: 66%

Long non‐coding RNA MYOSLID functions as a competing endogenous RNA to regulate MCL‐1 expression by sponging miR‐29c‐3p in gastric cancer

Han

Jiang

et al. 2019

Cell Proliferation

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Objective Long non‐coding RNA (lncRNA) has become an important regulator of many human malignancies. However, the biological role and clinical significance of most lncRNA in gastric cancer (GC) remain unclear. Methods We investigate the biological function, mechanism of action and clinical expression of lncRNA MYOSLID in GC. First, we analysed the differential expression of lncRNA MYOSLID in GC tissues and non‐cancerous tissues by analysing the sequencing data obtained from The Cancer Genome Atlas. Subsequently, we verified that lncRNA MYOSLID regulates the proliferation and apoptosis of GC cells by acting as a ceRNA against miR‐29c‐3p. The nude mouse xenograft was used to further confirm the functional significance of lncRNA MYOSLID in vivo. Results We found for the first time that the expression of lncRNA MYOSLID was significantly up‐regulated in GC tissues, and the up‐regulation of lncRNA MYOSLID in GC was correlated with tumour size, AJCC stage, depth of invasion and survival time. In addition, apoptosis and growth arrest can be induced in vitro after knockdown of lncRNA MYOSLID, which inhibits tumorigenesis in mouse xenografts in vivo. Further in‐depth studies revealed that lncRNA MYOSLID acts as a ceRNA of miR‐29c‐3p, resulting in de‐repression of its downstream target gene MCL‐1. Conclusion The lncRNA MYOSLID‐miR‐29c‐3p‐MCL‐1 axis plays a key role in the development of GC. Our findings may provide potential new targets for the diagnosis and treatment of human GC.

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“…33 In addition, it has been reported that miR-29c is significantly down-regulated in colon cancer. 34 In this study, we also found that miR-29c-3p…”

Section: Discussionsupporting

confidence: 66%

Long non‐coding RNA MYOSLID functions as a competing endogenous RNA to regulate MCL‐1 expression by sponging miR‐29c‐3p in gastric cancer

Han

Jiang

et al. 2019

Cell Proliferation

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“…And these data suggest that miR‐455‐5p functions as a potential oncogene in colon cancer by targeting galectin‐9 [10]. More and more microRNAs have been found to be related with colon cancer by regulating different targeting gene and signaling pathways, such as miR‐29c [11,12], miR‐93 [13] and miR‐148a [14]. Some results indicate that miR‐483‐3p could function as an antiapoptotic oncogene in various human cancer [15,16].…”

Section: Discussionmentioning

confidence: 87%

Mir‐483 inhibits colon cancer cell proliferation and migration by targeting TRAF1

Niu

Jiang

et al. 2018

The Kaohsiung J of Med Scie

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MicroRNAs are important regulators during human growth and development. Emerging evidence indicates that microRNAs play important roles in colorectal cancer. The aim of this study is to reveal the biological function and direct target gene of miR-483 in colorectal cancer. The biological function of miR-483 on the proliferation and migration of colon cancer cells was then examined by Edu assay and transwell assay, respectively. Our findings revealed that miR-483 mimic could significantly inhibit cell proliferation and migration. The target gene of miR-483 was predicted by target scan software and identified by a dual fluorescence reporter system which showed that TRAF1 was a direct target gene of miR-483 in SW480 cell line. These data suggest that miR-483 is a colorectal cancer suppressor which could inhibit cell proliferation and migration, possibly via targeting TRAF1. The miR-483 could be a potential treatment target for colorectal cancer.

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“…Moreover, miR-29 may also inhibit the expression of some genes involved in EMT and metastasis [24]. MiR-29c pertains to the miR-29 family and has been identified as markedly down-regulated microRNAs in cancer [14,15]. It plays a tumor suppressive role in multiple cancers, such as colorectal cancer [25], lung cancer [26], breast cancer [27], gastric cancer [28], and pancreatic cancer [29].…”

Section: Discussionmentioning

confidence: 99%

“…Recently, as a key miRNA, miR-29 has been reported to be involved in various major process of cancers, such as proliferation, apoptosis and metastasis, etc [14]. MiR-29c-3p, a member of the miR-29 family, was a potential tumor suppressor and it was down-regulated in several types of human cancers [15]. However, its role in OC remains to be elucidated.…”

Section: Introductionmentioning

confidence: 99%

MiR-29c-3p, a target miRNA of LINC01296, accelerates tumor malignancy: therapeutic potential of a LINC01296/miR-29c-3p axis in ovarian cancer

Mao

Zhao

et al. 2020

J Ovarian Res

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As one of the main gynecological cancers, ovarian cancer (OC) has an unfavourable outcomes owing to its high recurrence and metastasis rate. Our previous studies have revealed that LINC01296 functions as an oncogene in OC, but the underlying mechanism has not been explored. The aim of this paper was to further investigate that how LINC01296 plays a role in OC. Through online software prediction, miR-29c-3p has been discriminated as the target miRNA of LINC01296 for further research, and subsequent luciferase assay confirmed bioinformatics prediction. Then the data obtained from the two databases (GSE119055 and GSE83693) were analyzed by GEO2R for differential gene analysis. The results indicated that the miR-29c-3p was lowly expressed in OC tissues than that in normal ovarian tissues, and its expression in recurrent OC tissues was lower than that in primary OC tissues. Simultaneously, Kaplan-Meier survival analysis illustrated that the lower expression of miR-29c-3p was interrelated to unfavourable outcomes of OC. Further, the qRT-PCR data revealed that the miR-29c-3p expression in OC cell lines (SKOV-3 and OVCAR-3) was markedly declined than that in normal control cells (IOSE80). Subsequently, the functional experiments, such as CCK8, colony formation and Transwell assays, prompted that inhibition of miR-29c-3p can obviously increase the proliferation, invasion and migration of OVCAR3 and SKOV3 cells compared with control group, while downregulation of LINC01296 showed an opposite result. It is worth noting that downregulation of LINC01296 can reverse the effect of miR-29c-3p suppression on OC cells. Finally, we detected the changes of EMT-related proteins by western blot experiment, and reached a similar conclusion that knockdown of LINC01296 reversed the EMT caused by miR-29c-3p inhibition. In sum up, the cancer-promoting function of LINC01296 was achieved by regulating the expression of miR-29c-3p, and LINC01296/miR-29c-3p axis mediates the mechanical regulation of EMT in OC cells, hoping to provide the novel biomarkers and possibilities for OC therapy.

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p53 target miR-29c-3p suppresses colon cancer cell invasion and migration through inhibition of PHLDB2

Cited by 56 publications

References 22 publications

Long non‐coding RNA MYOSLID functions as a competing endogenous RNA to regulate MCL‐1 expression by sponging miR‐29c‐3p in gastric cancer

Long non‐coding RNA MYOSLID functions as a competing endogenous RNA to regulate MCL‐1 expression by sponging miR‐29c‐3p in gastric cancer

Mir‐483 inhibits colon cancer cell proliferation and migration by targeting TRAF1

MiR-29c-3p, a target miRNA of LINC01296, accelerates tumor malignancy: therapeutic potential of a LINC01296/miR-29c-3p axis in ovarian cancer

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