p53 regulates maternal reproduction through LIF

Hu, Wenwei; Feng, Zhaohui; Teresky, Angelika K.; Levine, Arnold J.

doi:10.1038/nature05993

Cited by 403 publications

(384 citation statements)

References 18 publications

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“…LIF is the cytokine produced and secreted by the endometrium, regulating implantation [6]. Sufficient uterine LIF protein is an essential condition for implantation.…”

Section: Discussionmentioning

confidence: 99%

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Negative effect of P72 polymorphism on p53 gene in IVF outcome in patients with repeated implantation failure and pregnancy loss

Lledó

Turienzo

Ortíz

et al. 2013

J Assist Reprod Genet

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Purpose Investigate whether R72P on p53 gene polymorphism has a higher prevalence among women with a history of recurrent implantation failure (RIF) and pregnancy loss (RPL) and its influence in their IVF cycle outcome. Material and methods p53 polymorphism R72P has been studied in 181 women. The control group included 83 oocyte donors. In the study group 98 women were included: 44 with RIF and 54 with RPL. From the study group, 76 patients underwent IVF-cycles (55 RPL and 21 RIF). Results The frequency of PP genotypes on p53 among RIF was 11.4 % compared with 18.5 % for RPL and 6 % in controls (p <0.01). There were no significant differences with respect to patient characteristics. Significant differences were reported in pregnancy rate (69.4 % for RR/RP and 33.3 % for PP; p < 0.05), embryo implantation rate (33.3 % for RR/RP and 7.3 % for PP; p <0.05) and ongoing pregnancy rate (53.1 % for RR/ RP and 14.3 % for PP; p <0.05) among RIF and RPL. Conclusions This investigation reveals that in RIF and RPL patients R72P on p53 gene is more prevalent than fertile population. Moreover, patients carrying a PP genotype on p53 codon 72 will have less chance to achieve an ongoing pregnancy. This information together with some additional markers will allow development of diagnostic tests for detects risk for RIF and RPL before infertility treatment is initiated.

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“…LIF is the cytokine produced and secreted by the endometrium, regulating implantation [6]. Sufficient uterine LIF protein is an essential condition for implantation.…”

Section: Discussionmentioning

confidence: 99%

“…Low expression of apoptosis and angiogenesis related genes have been associated with implantation failure [3]. Moreover, recent studies have demonstrated that p53 regulates female reproduction and blastocyst implantation through leukemia inhibitor factor (LIF) [6].…”

Section: Introductionmentioning

confidence: 99%

Negative effect of P72 polymorphism on p53 gene in IVF outcome in patients with repeated implantation failure and pregnancy loss

Lledó

Turienzo

Ortíz

et al. 2013

J Assist Reprod Genet

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“…For instance, leukaemia-inhibitory factor-a cytokine critical for embryo implantation-was identified as a p53-regulated gene (Hu et al, 2007). Moreover, p53 has been shown to induce as many as 40 genes that can somewhat, though not directly, have antiapoptotic effects (Janicke et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

p53 promotes cellular survival in a context-dependent manner by directly inducing the expression of haeme-oxygenase-1

Nam

Sabapathy

2011

Oncogene

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“…4 Mutated p53 is frequently found in human cancers. 5 and predisposes Li-Fraumeni syndrome patients to cancer.…”

Section: Introductionmentioning

confidence: 99%

Mutant mouse p53 transgene elevates the chemical induction of tumors that respond to gene silencing with siRNA

Tazaki¹,

Tatsumi²,

Tsuji³

et al. 2009

Cancer Gene Ther

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To study the role of mutant p53 in the induction and cure of tumors, we generated transgenic mice carrying mutant p53 (mp53) containing a 9 bp deletion in exon 6 in addition to wild-type p53, expressing both p53 and mp53. The mp53 cDNA was cloned from a radiation-induced mouse tumor and ligated to the chicken b-actin promoter/CMV-IE enhancer in the expression vector. The presence of mp53 suppressed p21 expression in primary fibroblasts after ionizing irradiation, indicating the dominant-negative activity of mp53 in the mice. These mice developed fibrosarcomas after the subcutaneous injection of 3-methylcholanthrene with an incidence 1.7-fold higher than that of wild-type mice (42% excess). The tumors were then treated via a potent atelocollagen delivery system with small interfering RNA (siRNA), that targeted the promoter/enhancer of the expression vector, resulting in the suppression of tumor growth in 30% of 44 autochthonous tumors, including four cures, and their transplants, the total fraction corresponding to the tumor excess. This suppressive effect involved the induction of apoptosis. These results indicate that mp53 activity causes tumors that can be suppressed by subsequent silencing of mp53 in the presence of wild-type p53 alleles.

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p53 regulates maternal reproduction through LIF

Cited by 403 publications

References 18 publications

Negative effect of P72 polymorphism on p53 gene in IVF outcome in patients with repeated implantation failure and pregnancy loss

Negative effect of P72 polymorphism on p53 gene in IVF outcome in patients with repeated implantation failure and pregnancy loss

p53 promotes cellular survival in a context-dependent manner by directly inducing the expression of haeme-oxygenase-1

Mutant mouse p53 transgene elevates the chemical induction of tumors that respond to gene silencing with siRNA

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