p53 Protein and Proliferating Cell Nuclear Antigen in Eccrine Poroma and Porocarcinoma An Immunohistochemical Study

Tateyama, Hisashi; Eimoto, Tadaaki; Tada, Toyohiro; Inagaki, Hiroshi; Nakamura, Takaaki; Yamauchi, Ritsuko

doi:10.1097/00000372-199510000-00005

Cited by 22 publications

(9 citation statements)

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“…Our study further benefits from correlation with mutation status of the relevant genes in a subset of cases. Some previous reports have not found a significant difference between poromas and porocarcinomas in the percentage of cells labeling for p53 [9][10][11][12][13] ; however, many of these studies did not account for staining intensity. In our cohort, a high percentage of cells in poromas showed weak p53 staining; evaluation of p53 staining intensity was therefore critical for distinguishing mutation-associated p53 overexpression in porocarcinoma from diffuse but predominantly weak expression in poromas.…”

Section: Rb P53 and P16 Immunohistochemistry Performance As A Diamentioning

confidence: 85%

“…Previous studies have examined p53, Rb, or p16 staining in the context of poromas and/or porocarcinomas, although to our knowledge our study is the first to rigorously examine the combined performance of all three markers. Our study further benefits from correlation with mutation status of the relevant genes in a subset of cases.…”

Section: Discussionmentioning

confidence: 99%

“…Previous immunohistochemical studies on these markers in poromas and porocarcinomas have been limited and yielded contradictory results. 4,[8][9][10][11][12][13][14] Our initial studies indicated that p53 expression may correlate with TP53 mutation status in porocarcinomas, 4 with dominant negative mutations associated with overexpression of p53 protein predicted to lack tumor suppressor activity, and truncating mutations associated with diffuse loss of p53 expression. We investigated whether p53, Rb, and p16 marker expression correlated with mutational status in porocarcinomas, and whether a panel immunohistochemistry approach including these tumor suppressors distinguished porocarcinomas from poromas.…”

Section: Introductionmentioning

confidence: 97%

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Altered Rb, p16, and p53 expression is specific for porocarcinoma relative to poroma

et al. 2019

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Background Porocarcinomas are rare aggressive carcinomas that harbor tumor suppressor mutations and must be distinguished from benign entities such as poromas. Methods To determine whether altered expression of these genes was diagnostically informative, we examined p53, Rb, and p16 staining patterns in 15 poromas and 16 porocarcinomas. Results Poromas consistently displayed diffuse strong expression of Rb in all but one case that displayed focal loss (1/15, 7%), and no evidence of aberrancy in p53 or p16. Porocarcinomas displayed diffuse or focal loss of Rb expression in 9/16 (56%) cases, diffuse loss or overexpression of p53 in 8/15 (53%), and diffuse loss or overexpression of p16 in 6/14 (43%). Diffuse aberrancy in p53 and Rb expression correlated with tumor mutations in TP53 and RB1, respectively, whereas focal Rb loss was associated with wild type RB1. Diffuse p16 overexpression correlated with Rb loss rather than CDKN2A mutation. For porocarcinomas with all three stains evaluable, 10/13 (77%) displayed aberrancy in at least one marker. Conclusions Our findings suggest that altered p53, p16, and/or Rb expression is relatively specific to porocarcinoma in comparison with poroma. Technical limitations of this panel, including possible focal Rb loss, must be kept in mind, especially in limited samples.

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Section: Rb P53 and P16 Immunohistochemistry Performance As A Diamentioning

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

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Altered Rb, p16, and p53 expression is specific for porocarcinoma relative to poroma

et al. 2019

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“…Limited prior studies have focused on the status of selected tumor suppressor genes, including p53, the adenomatous polyposis coli gene, p16, and the retinoblastoma gene. [14][15][16][17] However, these studies do not identify any defining genetic aberration. Thus a more broad-based molecular approach may be necessary to fully elucidate specific gene defects involved in eccrine poroma tumorigenesis.…”

Section: Discussionmentioning

confidence: 97%

Multiple eccrine poromas in the setting of total body irradiation and immunosuppression

Mahlberg

McGinnis

Fakharzadeh

2006

Journal of the American Academy of Dermatology

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“…Tateyama et al reported that proliferating cell nuclear antigen (PCNA) positive cells in eccrine porocarcinomas were significantly higher than those in poromas (9). They have also described that the PCNA index is useful in differentiating between poroma and porocarcinoma.…”

Section: Introductionmentioning

confidence: 99%

An Assessment of the Malignant Potential of Actinic Keratoses and Bowen's Disease: p53 and PCNA Expression Pattern Correlate with the Number of Desmosomes

Ramzi

Maruno

Khaskhely

et al. 2002

The Journal of Dermatology

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Actinic keratoses (AK) and Bowen's disease (BD), both intraepidermal skin tumors, have a potential progression to squamous cell carcinoma (SCC). To evaluate the malignant potential of AK and BD, the expression pattern of p53 protein and proliferating cell nuclear antigen (PCNA) were examined in five types of AK and BD by immunohistochemistry. The ultrastructural difference of epidermal cells between AK and BD lesions was investigated. In the study of p53 and PCNA expression, the atrophic and acantholytic types of AK showed lower positive rates compared to others. These two types did not demonstrate all layers expression pattern. The number of desmosomes of the epidermal cells was significantly reduced in BD, and in the bowenoid and hypertrophic types of AK compared with other types of AK The number of hemi-desmosomes showed greatest reduction in BD and the bowenoid type of AK On the basis of our findings, it is hypothesized that atrophic and acantholytic types of AK may have the lowest, and the bowenoid type of AK and BD may have the highest, malignant potential.

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p53 Protein and Proliferating Cell Nuclear Antigen in Eccrine Poroma and Porocarcinoma An Immunohistochemical Study

Cited by 22 publications

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Altered Rb, p16, and p53 expression is specific for porocarcinoma relative to poroma

Altered Rb, p16, and p53 expression is specific for porocarcinoma relative to poroma

Multiple eccrine poromas in the setting of total body irradiation and immunosuppression

An Assessment of the Malignant Potential of Actinic Keratoses and Bowen's Disease: p53 and PCNA Expression Pattern Correlate with the Number of Desmosomes

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