P53 nuclear stabilization is associated with FHIT loss and younger age of onset in squamous cell carcinoma of oral tongue

Abstract

BackgroundSquamous cell carcinoma of tongue (SCCT) is expected to harbor unique clinico-pathological and molecular genetic features since a significant proportion of patients are young and exhibit no association with tobacco or alcohol.MethodsWe determined P53, epidermal growth factor receptor, microsatellite instability, human papilloma virus infection and loss of heterozygosity status at several tumor suppressor loci in one hundred and twenty one oral SCCT (SSCOT) samples and analyzed their association with clinico-pathological features and patient survival.ResultsOur results revealed a significantly higher incidence of p53 nuclear stabilization in early (as against late) onset SCCOT. FHIT loss was significantly associated with p53 nuclear stabilization and the association was stronger in patients with no history of tobacco use. Samples harboring mutation in p53 DNA binding domain or exhibiting p53 nuclear stabilization, were significantly associated with poor survival.ConclusionOur study has therefore identified distinct features in SCCOT tumorigenesis with respect to age and tobacco exposure and revealed possible prognostic utility of p53.

Epidemiological profile of young patients with squamous cell carcinoma in northeast Brazil

“…Tobacco and alcohol use were lower among the women with SCC evaluated in the present study compared to their male counterparts, which is consistent with the scientific literature . Therefore other etiologic factors for SCC development are suggested in young patients, especially women, such as nutritional deficiencies, genetic susceptibility, and HPV …”

Clinicopathological characteristics and outcomes of squamous cell carcinoma of the tongue in different age groups

“…Several researchers had made efforts to study the underlying molecular and genomic causes. Although some believe that disease development and progression could be attributed to the role of a virus, others suggest some specific gene overexpression in patients with tongue SCC; however, the difference among diverse age groups was not significant . Although the exact biological cause and mechanism remain poorly understood, a remarkably high rate of tumor aneuploidy and tetraploidy in patients with tongue SCC aged <40 years has been observed, as compared to patients older than 50 years .…”

SMARCD1 is a transcriptional target of specific non‐hotspot mutant p53 forms

“…The study was approved by ethics committees of the respective hospitals (listed previously; Adduri & Kotapalli et al, ) and the Institutional Bioethics Committee of the Center for DNA Fingerprinting and Diagnostics (CDFD) as per the revised Helsinki declaration (2005). Informed consent was obtained from patients.…”