p53 mutations and human papillomavirus infection in oral squamous cell carcinomas: correlation with overall survival

Human Papilloma Virus in Oral Cavity Cancer and Relation to Change in Quality of Life Following Treatment—a Pilot Study from Northern India

“…In contrast to the clear picture in OPC [7,51,62], where the prognostic relevance of biologically active HPV infection is established, no such clear association has been found in OCSCC. Published literature is divided between the improved likelihood for HPV-positive OCSCC on one hand [63,64] and worst outcome on the other [65][66][67] with no clout on patient survival [10,37,68].…”

Relevance of human papilloma virus (HPV) infection to carcinogenesis of oral tongue cancer

“…KOZOMARA et al reported an HPV prevalence rate of 64% (32/50) in oral cavity cancer (mostly oral tongue). They also reported that most infections were highrisk HPVs and HPV infection was related to poor prognosis 14 . dA SILVA et al reported a high prevalence rate for HPV (74%) in oral tongue cancer using a PCR assay with fresh tissue 8 .…”

HPV and cancer of the oral cavity

“…5 In contrast to the clear picture in OPSCC, where the prognostic relevance of biologically active HPV infection is established, 18,43,44 no such clear association can be found for OSCC. Contradictory studies exist, which are either in favor of a better survival probability for HPV-positive OSCC patients 45,46 or of worse outcome, [47][48][49] as well as supporting no effect on patient survival. 24,50,51 A number of publications analyzing larger cohorts underline that HPV DNA and especially HPV16 is present in 10-25% of tumors of the oral cavity, which is higher than in the healthy control population but smaller than in OPSCC.…”