P53 Mutation at Codon 249 is Uncommon in Neonatal Kotb Disease Biliary Atresia
Magd Kotb,
Ayda Kelany,
Sherif Shehata
et al.
Abstract:Background: Hepatocellular carcinoma (HCC) is known to result from aflatoxin B1 that induces p53 mutation at codon 249. Aflatoxins are also known to cause The Kotb disease Biliary atresia (BA) variant which is characterized by congenital aflatoxicosis B1 in neonates with null glutathione S transferase M1.
Aim of the Work:We aimed to search for the aflatoxin B1 induced HCC 249 codon p53 mutation among neonates with Kotb disease BA variant and their mothers. Patients and Methods: This study included 13 neonates … Show more
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