P53 long noncoding RNA regulatory network in cancer development

Abstract

The protein p53 as a transcription factor with strong tumor-suppressive activities is known to trigger apoptosis via multiple pathways and is directly involved in the recognition of DNA damage and DNA repair processes. P53 alteration is now recognized as a common event in the pathogenesis of many types of human malignancies. Deregulation of tumor suppressor p53 pathways plays an important role in the activation of cell proliferation or inactivation of apoptotic cell death during carcinogenesis and tumor progression. Mounting evidence indicates that the p53 status of tumors and also the regulatory functions of p53 may be relevant to the long noncoding RNAs (lncRNA)-dependent gene regulation programs. Besides

A comprehensive model for the implementation of agricultural land levelling and consolidation plan in the Abu Fazel region of Ahvaz

“…Other positive results of consolidation projects include increasing the production and yield of crops in the villages under study. The results of studies such as Roozitalab and Majidi (2017), Aravindhan et al (2021), Barzamini and Ghassemian (2019), Kupidura et al (2014), Daneii et al (2022), Sarvaramini et al (2021) also confirm the research results of our study. Also, with the implementation of the land consolidation plan, positive changes can be experienced in the use of machinery in different stages of production of agricultural products, especially in the harvest stage of products such as wheat, barley and potatoes.…”

“…1-Reduced production costs and increased efficiency of production factors (Wu et al, 2005), 2-Increased irrigation efficiency and increased arable lands under cultivation (Aravindhan et al, 2021;Bozorgkhou and Hakimipour, 2014), 3-Reducing the need for labour, 4-Optimal land use and reducing soil erosion (Yu et al, 2010), 5-Protecting the environment (Sonnenberg, 2002), and, 6-Facilitating the implementation of political, macro and infrastructural decisions and ease of providing extension services (Van der Molen et al, 2005).…”

Ovotransferrin Inhibits TNF-α Induced Inflammatory Response in Gastric Epithelial Cells via MAPK and NF-κB Pathway

“…Additionally, from the results of RNA-seq analysis, the KEGG pathway showed that p53, the cancer signaling pathway, was also remarkably enriched, besides the inflammation-related pathway. The transcription factor p53 is a major tumor suppressor and participates in cell cycle regulation and the induction of apoptosis . Multiple inflammatory signaling pathways (NF-κB and MAPK signaling pathways etc.)…”

“…The transcription factor p53 is a major tumor suppressor and participates in cell cycle regulation and the induction of apoptosis. 48 Multiple inflammatory signaling pathways (NF-κB and MAPK signaling pathways etc.) are associated with cancer, which regulates the release of proinflammatory cytokines and may activate oncogenic pathways.…”

Long Noncoding RNA 00472: A Novel Biomarker in Human Diseases

“…Emerging evidence suggests that p53 can activate downstream targets to initiate cell cycle arrest and apoptosis. Moreover, several lncRNAs are involved in the p53 signaling network where they are p53 effectors or modulators ( Li et al, 2020b ; Chaleshi et al, 2020 ; Chen et al, 2020 ; Lu et al, 2020 ; Aravindhan et al, 2021 ; Xu et al, 2021e ; Liu et al, 2021g ; Lu et al, 2021 ; Wu et al, 2021 ). For instance, lncRNA GClnc1 contributes to ovarian cancer growth via p53 signaling pathway regulation ( Li et al, 2020b ).…”