p53 Isoforms as Cancer Biomarkers and Therapeutic Targets

Zhao, Liuqun; Sanyal, Suparna

doi:10.3390/cancers14133145

Cited by 19 publications

(23 citation statements)

References 178 publications

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“…The p53 protein regulates the appearance of its downstream effector genes, whose expressions are related to critical cellular actions such as DNA repair, cell cycle control, and apoptosis. Overexpression of the p53 protein is a cellular reaction to genotoxic stress [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

The Association of Increased Oxidative Stress and Tumor Biomarkers Related to Polyaromatic Hydrocarbons Exposure for Different Occupational Workers in Makkah, Saudi Arabia

Adly¹,

Saleh²

2022

Cureus

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Introduction: Exposure to occupational polyaromatic hydrocarbons (PAHs) is correlated with several adverse effects on human health, including bladder, lung, and skin cancer. The correlation between PAH exposure and oxidative stress and tumor markers needs to be further explored. Therefore, we conducted this study to examine the effect of acute exposure to PAHs on oxidative stress and tumor marker levels in occupational workers during the Hajj season in Makkah. Methods: We conducted a cross-sectional study of 105 workers during Hajj; 60 workers were employed in the open air for ≥eight hours/day, exposed them to high levels of considerable traffic and huge crowds, and 45 workers served as our control group who were unexposed and working in a rural area. Using high-performance liquid chromatography, we analyzed participants' urinary 1-hydroxypyrene to determine PAH levels. Oxidative stress markers malondialdehyde (MDA), glutathione S-transferase (GST), and lactate dehydrogenase (LDH) were analyzed in serum using a spectrophotometer. The serum p53 and p21 proteins were analyzed using an enzyme-linked immunosorbent assay. We used IBM SPSS Statistics for Windows, Version 21.0 (IBM Corp., Armonk, NY, USA) to calculate multivariate logistic regression analysis for oxidative stress and tumor markers such as age, working period, and smoking status risk factors. Additionally, we evaluated associations between oxidative stress and tumor markers. Results: The mean levels of MDA, GST, and LDH were significantly elevated in exposed workers compared to the control group (p<.001). Also, p53 and p21 protein levels were significantly higher in the occupationally exposed group than in the unexposed control group (p<0.05). No significant correlation between age and increased levels of p53 and p21 was found. Conclusions: In our study, PAH exposure is significantly correlated with higher levels of oxidative stress and tumor marker levels in occupational workers. The evaluation of oxidative stress and tumor marker indicators can efficiently identify workers at high risk of PAH exposure and may assist in preventing future health concerns. More biomarkers should be included in other longitudinal studies to address exposure related to different health risks among workers, especially cancer risk. More prospective studies are required to validate diagnostic utilities and efficiencies of different biomarker combinations.

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Section: Discussionmentioning

confidence: 99%

The Association of Increased Oxidative Stress and Tumor Biomarkers Related to Polyaromatic Hydrocarbons Exposure for Different Occupational Workers in Makkah, Saudi Arabia

Adly¹,

Saleh²

2022

Cureus

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“…p53 is one of the most frequently mutated genes in cancer, in the early phases of lung, skin, esophageal, and other cancers. − p53 aggregates have been identified as prognostic marker in ovarian cancer . Mutant p53 is viewed as a biomarker for breast cancer as well as head and neck squamous cell carcinoma, and may help improve cancer surgery results…”

Section: Biomarker Research Growthmentioning

confidence: 99%

Biomarkers for Early Cancer Detection: A Landscape View of Recent Advancements, Spotlighting Pancreatic and Liver Cancers

Tenchov,

Sapra,

Sasso

et al. 2024

ACS Pharmacol. Transl. Sci.

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Cancer is one of the leading causes of death worldwide. Early cancer detection is critical because it can significantly improve treatment outcomes, thus saving lives, reducing suffering, and lessening psychological and economic burdens. Cancer biomarkers provide varied information about cancer, from early detection of malignancy to decisions on treatment and subsequent monitoring. A large variety of molecular, histologic, radiographic, or physiological entities or features are among the common types of cancer biomarkers. Sizeable recent methodological progress and insights have promoted significant developments in the field of early cancer detection biomarkers. Here we provide an overview of recent advances in the knowledge related to biomolecules and cellular entities used for early cancer detection. We examine data from the CAS Content Collection, the largest human-curated collection of published scientific information, as well as from the biomarker datasets at Excelra, and analyze the publication landscape of recent research. We also discuss the evolution of key concepts and cancer biomarkers development pipelines, with a particular focus on pancreatic and liver cancers, which are known to be remarkably difficult to detect early and to have particularly high morbidity and mortality. The objective of the paper is to provide a broad overview of the evolving landscape of current knowledge on cancer biomarkers and to outline challenges and evaluate growth opportunities, in order to further efforts in solving the problems that remain. The merit of this review stems from the extensive, wide-ranging coverage of the most up-to-date scientific information, allowing unique, unmatched breadth of landscape analysis and in-depth insights.

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“…The p53 protein is a regulator of many processes that cells need to function correctly, and it is involved in many processes related to their life and death [141]. The p53 protein inhibits the growth of tumors by controlling the expression of a vast number of genes involved in processes such as cell cycle arrest, DNA repair, senescence, apoptosis, cell motility, cell adhesion, and migration [142].…”

Section: The Relationship Between Bcl-2 Protein Family and P53mentioning

confidence: 99%

Emerging Biomarkers and Potential Therapeutics of the BCL-2 Protein Family: The Apoptotic and Anti-Apoptotic Context

Paul¹,

Saddam²,

Habib³

et al. 2023

Preprint

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Apoptosis, also known as the programmed death of cells, is responsible for maintaining the homeostasis of tissues and this function is carried out by caspases. The process of apoptosis is carried out via two distinct pathways: the extrinsic pathway, which is governed by death receptors, and the intrinsic pathway, also known as the mitochondrial pathway. The BCL-2 protein family encoded by the BCL-2 gene, located at the 18q21.33 chromosomal location, is in charge of regulating the intrinsic pathway, which is responsible for inducing cell death via the permeabilization of the mitochondrial membrane and the release of apoptosis - inducing components. The BCL-2 homology (BH1, BH2, BH3, BH4) domains of this family proteins are crucial for their functioning and their common BH domains allow interactions between members of the same family and can also serve as indications of pro- or anti-apoptotic activity. A direct correlation may be shown between the overexpression of BCL-2 and the postponement of cell death. It has been determined that a change in the expression of BCL-2 is the root cause of a variety of malignancies, including lung, breast, melanoma, and chronic lymphocytic leukemia, Multiple Sclerosis, Diabetes. In this review, we discuss the therapeutic potential of regulating BCL-2 family connections and their relevance to health and disease.

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p53 Isoforms as Cancer Biomarkers and Therapeutic Targets

Cited by 19 publications

References 178 publications

The Association of Increased Oxidative Stress and Tumor Biomarkers Related to Polyaromatic Hydrocarbons Exposure for Different Occupational Workers in Makkah, Saudi Arabia

The Association of Increased Oxidative Stress and Tumor Biomarkers Related to Polyaromatic Hydrocarbons Exposure for Different Occupational Workers in Makkah, Saudi Arabia

Biomarkers for Early Cancer Detection: A Landscape View of Recent Advancements, Spotlighting Pancreatic and Liver Cancers

Emerging Biomarkers and Potential Therapeutics of the BCL-2 Protein Family: The Apoptotic and Anti-Apoptotic Context

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