p53 in the game of transposons

Wylie, Annika; Jones, Amanda E.; Abrams, John

doi:10.1002/bies.201600115

Cited by 24 publications

(18 citation statements)

References 63 publications

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“…In vivo studies on Drosophila and zebrafish models show higher transposon expression in p53 knockout animals than in their wild type counterparts. Consistent with these observations, p53 also mediates retrotransposon de-repression in human and mouse cancers, suggesting that p53 controls transposon mobility [87,88]. However, this hypothesis is based on a correlative observation and formal experimental proof is lacking.…”

Section: Maintenance Of Genome Stabilitymentioning

confidence: 85%

p53-Mediated Tumor Suppression: DNA-Damage Response and Alternative Mechanisms

Pitolli

Wang

Candi

et al. 2019

Cancers

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The tumor suppressor p53 regulates different cellular pathways involved in cell survival, DNA repair, apoptosis, and senescence. However, according to an increasing number of studies, the p53-mediated canonical DNA damage response is dispensable for tumor suppression. p53 is involved in mechanisms regulating many other cellular processes, including metabolism, autophagy, and cell migration and invasion, and these pathways might crucially contribute to its tumor suppressor function. In this review we summarize the canonical and non-canonical functions of p53 in an attempt to provide an overview of the potentially crucial aspects related to its tumor suppressor activity.

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Section: Maintenance Of Genome Stabilitymentioning

confidence: 85%

p53-Mediated Tumor Suppression: DNA-Damage Response and Alternative Mechanisms

Pitolli

Wang

Candi

et al. 2019

Cancers

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“…In a way, under normal conditions, p53 acts to suppress genomic instability contributed by transposition but enhances genomic instability by means of transposition following certain stresses or insults. The latter point is interesting given that some transposons are reportedly derepressed in human cancers [138] and the findings that common hotspot DBD mutants of p53 fail to suppress transposition [131].…”

Section: Suppression Of Transpositionmentioning

confidence: 99%

How the Other Half Lives: What p53 Does When It Is Not Being a Transcription Factor

Tan

Lane

2019

IJMS

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It has been four decades since the discovery of p53, the designated ‘Guardian of the Genome’. P53 is primarily known as a master transcription factor and critical tumor suppressor, with countless studies detailing the mechanisms by which it regulates a host of gene targets and their consequent signaling pathways. However, transcription-independent functions of p53 also strongly define its tumor-suppressive capabilities and recent findings shed light on the molecular mechanisms hinted at by earlier efforts. This review highlights the transcription-independent mechanisms by which p53 influences the cellular response to genomic instability (in the form of replication stress, centrosome homeostasis, and transposition) and cell death. We also pinpoint areas for further investigation in order to better understand the context dependency of p53 transcription-independent functions and how these are perturbed when TP53 is mutated in human cancer.

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“…In different models ( Drosophila , mouse, zebrafish, and human cultured cells), p53 mutation leads to TE derepression associated with a piRNA biogenesis defect, at least in Drosophila [180]. Accordingly, p53 -derived cancers have been considered as ‘transposopathies’, diseases induced by TE mobilization resulting in genome instability [181]. However, even though TE insertions have been detected in several cases of cancers, it is still unclear whether they are the direct cause of cancer development or a consequence of another cellular defect causing cancer.…”

Section: Speculative Insights On Transgenerational Pirna Inheritanmentioning

confidence: 99%

Environmentally-Induced Transgenerational Epigenetic Inheritance: Implication of PIWI Interacting RNAs

Casier

Boivin

Carré

et al. 2019

Cells

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Environmentally-induced transgenerational epigenetic inheritance is an emerging field. The understanding of associated epigenetic mechanisms is currently in progress with open questions still remaining. In this review, we present an overview of the knowledge of environmentally-induced transgenerational inheritance and associated epigenetic mechanisms, mainly in animals. The second part focuses on the role of PIWI-interacting RNAs (piRNAs), a class of small RNAs involved in the maintenance of the germline genome, in epigenetic memory to put into perspective cases of environmentally-induced transgenerational inheritance involving piRNA production. Finally, the last part addresses how genomes are facing production of new piRNAs, and from a broader perspective, how this process might have consequences on evolution and on sporadic disease development.

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p53 in the game of transposons

Cited by 24 publications

References 63 publications

p53-Mediated Tumor Suppression: DNA-Damage Response and Alternative Mechanisms

p53-Mediated Tumor Suppression: DNA-Damage Response and Alternative Mechanisms

How the Other Half Lives: What p53 Does When It Is Not Being a Transcription Factor

Environmentally-Induced Transgenerational Epigenetic Inheritance: Implication of PIWI Interacting RNAs

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