2014
DOI: 10.1007/s00262-014-1529-8
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P53, hTERT, WT-1, and VEGFR2 are the most suitable targets for cancer vaccine therapy in HLA-A24 positive pancreatic adenocarcinoma

Abstract: Cancer vaccine therapy is one of the most attractive therapies as a new treatment procedure for pancreatic adenocarcinoma. Recent technical advances have enabled the identification of cytotoxic T lymphocyte (CTL) epitopes in various tumor-associated antigens (TAAs). However, little is known about which TAA and its epitope are the most immunogenic and useful for a cancer vaccine for pancreatic adenocarcinoma. We

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Cited by 16 publications
(12 citation statements)
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“…18,19 Thus, p53 protects against tumor development via the Akt, NF-kb, and hTERT pathways. [20][21][22] In addition, a few studies have reported that p38 is regulated by p53 to induce cancer cell apoptosis, 23,24 and our results have shown that the expression of p38 is not affected by amarogentin in liver cancer cells. In our study, amarogentin also suppressed the expression of Akt, NF-kb, and hTERT.…”
Section: Discussionsupporting
confidence: 61%
“…18,19 Thus, p53 protects against tumor development via the Akt, NF-kb, and hTERT pathways. [20][21][22] In addition, a few studies have reported that p38 is regulated by p53 to induce cancer cell apoptosis, 23,24 and our results have shown that the expression of p38 is not affected by amarogentin in liver cancer cells. In our study, amarogentin also suppressed the expression of Akt, NF-kb, and hTERT.…”
Section: Discussionsupporting
confidence: 61%
“…Multiple studies demonstrate that the highly immunosuppressive tumor microenvironment plays an important role in the development and progression of PC 5‐8 . T‐cell dysfunction and depletion caused by failure of the immune system are considered responsible for generating an immunosuppressive tumor microenvironment 9,10 . However, the detailed mechanics of the interactions between tumors and T lymphocytes are poorly understood.…”
Section: Introductionmentioning
confidence: 99%
“…The observed frequency of TAA-specific IFNγ-producing T cells in the peripheral blood was 10-219 cells/3 × 10 5 PBMCs. Previous findings from HCC and pancreatic adenocarcinoma demonstrated 10-60.5 and 10-46 cells/3 × 10 5 PBMCs, 42,44 respectively, suggesting that cholangiocarcinoma has high immunogenicity.…”
Section: Ta B L E 4 Epitopes That Elicited Patient-specific Immune Rementioning
confidence: 88%