p53 gene mutation analysis in porokeratosis and porokeratosis-associated squamous cell carcinoma

Ninomiya, Yoshiro; Urano, Yoshio; Yoshimoto, Katsuhiko; Iwahana, Hiroyuki; Sasaki, Shiro; Arase, Seiji; Itakura, Mitsuo

doi:10.1016/s0923-1811(96)00569-5

Cited by 27 publications

(24 citation statements)

References 23 publications

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“…Overexpression of p53 can be induced by p53 gene mutations and other DNA damaging agents, such as ultraviolet (UV) light and ionizing radiation. In a previous study, mutations of the p53 gene were not detected in porokeratotic lesions9. This finding suggests that other causative mechanisms exist for overexpression of p53 in the epidermis of porokeratotic lesions.…”

Section: Discussionmentioning

confidence: 71%

“…These findings indicate that there is a significant role of UV light on the evolution of squamous cell carcinoma from DSAP. In addition, results from previous reports show that p53 gene mutations are responsible for the progression of porokeratosis to SCC in at least some cases9.…”

Section: Discussionmentioning

confidence: 93%

“…The pathogenesis of DSAP is not clearly understood, but frequent p53 overexpression in the epidermis of porokeratotic lesions have been detected9. Overexpression of p53 can be induced by p53 gene mutations and other DNA damaging agents, such as ultraviolet (UV) light and ionizing radiation.…”

Section: Discussionmentioning

confidence: 99%

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Squamous Cell Carcinoma Developing within Lesions of Disseminated Superficial Actinic Porokeratosis

et al. 2011

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Disseminated superficial actinic porokeratosis (DSAP) consists of multiple annular, hyperkeratotic lesions that have a bilateral distribution on sun-exposed areas, particularly the extremities. DSAPs have a wider distribution than porokeratosis of Mibelli and usually develop during the 3rd or 4th decade of life. Squamous cell carcinoma that arises in the classical type of porokeratosis of Mibelli is well-documented, but there are only a few reports of squamous cell carcinoma in DSAP. Here, we describe a 62-year-old man with DSAP who developed squamous cell carcinoma on his right forearm.

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Section: Discussionmentioning

confidence: 71%

Section: Discussionmentioning

confidence: 93%

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Squamous Cell Carcinoma Developing within Lesions of Disseminated Superficial Actinic Porokeratosis

et al. 2011

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“…Our observations indicate that mutations of the p53 gene are not the major molecular etiology for porokeratosis, but are related to its skin carcinogenesis, and that p53 overexpression in porokeratosis is not due to p53 gene mutations. 17 Christine Liang reported a 22-year-old man(case 5), presented to the Dermatology Clinic at Bellevue Hospital Center in July, 2008, with a two-year history of warts on the shaft of his penis, thighs, scrotum, and perianal area. An external biopsy report brought in by the patient had been interpreted as condyloma acuminata.…”

Section: Discussionmentioning

confidence: 99%

Porokeratosis with an Invasive Squamous Cell Carcinoma: A Case Report and Review of Literature

Nessa¹,

Khondker

Bari

et al. 2014

J. Bangladesh Coll. Phys.

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Porokeratosis is a clonal disorder of epidermal keratinization, which is characterized by hyperkeratotic papules or plaques that are surrounded by a thread-like elevated border. The histopathologic hallmark of porokeratosis is the cornoid lamella, which is a thin column of parakeratosis that overlies a thin or absent granular layer and that corresponds to the raised, hyperkeratotic border. Porokeratosis has five clinical types and malignant degeneration has been described in all forms of porokeratosis. We report a forty five year old farmer with a large plaque in chest for 30 years and multiple nodules within the large plaque for 2 years. A section of skin from margin of the plaque reveals histopathological features of porokeratosis and section from nodules reveals an invasive squamous cell carcinoma. To the best of our knowledge, this is the first reported case of porokeratosis transformed to squamous cell carcinoma on Bangladesh.

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“…The coexistence of different variants of PK in a single patient or in different members of an affected family (7,8) is considered to be the different phenotypic expression of a common genetic disorder. In patients with genetic predisposition, external triggering factors such as irradiation, infective agents, trauma and immunosuppression can determine the activation of an abnormal clone of epidermal keratinocytes (9 ± 11) and this could explain the high incidence of cutaneous malignancies reported in patients with PK (12,13).…”

mentioning

confidence: 99%

Porokeratosis in the Elderly: A New Subtype of Disseminated Superficial Actinic Porokeratosis

Patrizi

D'Acunto²,

Passarini³

et al. 2000

Acta Dermato-Venereologica

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In a review of all cases of porokeratosis histologically diagnosed in our Department during the period 1991-98 we found that 12 patients (22%) were in their seventh to ninth decade. In all 12 (2 males and 10 females) the age of onset of the disease varied between 58 and 89 years (mean age 68.6 years). The clinical picture was similar in all the patients, with the number of lesions varying from a few to 20-50 annular plaques 10-15 mm in diameter, localized mainly on the lower limbs. We suggest that our patients had a very mild form of disseminated superficial actinic porokeratosis confined to the extremities with an unusually late onset. This peculiar variety of late-onset disseminated superficial actinic porokeratosis may represent a type of immunosuppression-induced porokeratosis where the pathologic clone for porokeratosis is present but remains latent until the amount of sun exposure, together with the physiological age-related lowering of immunocompetence, bring about its proliferation.

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p53 gene mutation analysis in porokeratosis and porokeratosis-associated squamous cell carcinoma

Cited by 27 publications

References 23 publications

Squamous Cell Carcinoma Developing within Lesions of Disseminated Superficial Actinic Porokeratosis

Squamous Cell Carcinoma Developing within Lesions of Disseminated Superficial Actinic Porokeratosis

Porokeratosis with an Invasive Squamous Cell Carcinoma: A Case Report and Review of Literature

Porokeratosis in the Elderly: A New Subtype of Disseminated Superficial Actinic Porokeratosis

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