p53 Function and Dysfunction in Human Health and Diseases

D’Orazi, Gabriella

doi:10.3390/biom13030506

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2024

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Cited by 3 publications

References 26 publications

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Integrated network pharmacology and phosphoproteomic analyses of Baichanting in Parkinson's disease model mice

Gao,

Fu,

et al. 2024

Heliyon

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Integrated network pharmacology and phosphoproteomic analyses of Baichanting in Parkinson's disease model mice

Gao,

Fu,

et al. 2024

Heliyon

View full text Add to dashboard Cite

The importance of protein domain mutations in cancer therapy

Chitluri,

Emerson

2024

Heliyon

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A mathematical model for pancreatic cancer during intraepithelial neoplasia

Briones-Andrade,

Ramírez-Santiago,

Romero-Arias

2024

Preprint

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Cancer is the result of complex interactions of intrinsic and extrinsic cell processes, which promote sustained proliferation, resistance to apoptosis, reprogramming and reorganization. To understand the evolution of any type of cancer it is necessary to understand the role of the microenvironmental conditions and the impact of some molecular complexes and mechanisms on certain signalling pathways. As in most cancer quantitative models, the understanding of the early onset of cancer requires a multiscale analysis of the cellular microenvironment. In this paper we analyse a multiscale model of pancreatic adenocarcinoma by modelling the cellular microenvironment through elastic cell interactions and their intercellular communication mechanisms, such as growth factors and cytokines. We focus on the low-grade dysplasia (PanIN 1) and moderate dysplasia (PanIN 2) stages of the pancreatic adenocarcinoma. To this end we propose a gene regulatory network associated with the processes of proliferation and apoptosis of pancreatic cells and its kinetics in terms delayed differential equations to mimic cell development. Likewise, we couple the cell cycle with the spatial distribution of cells and the transport of growth factors to show that the adenocarcinoma evolution is triggered by inflammatory processes. We show that the oncogene RAS may be an important target to develop anti-inflammatory strategies that limit the emergence of more aggressive adenocarcinomas.

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p53 Function and Dysfunction in Human Health and Diseases

Cited by 3 publications

References 26 publications

Integrated network pharmacology and phosphoproteomic analyses of Baichanting in Parkinson's disease model mice

Integrated network pharmacology and phosphoproteomic analyses of Baichanting in Parkinson's disease model mice

The importance of protein domain mutations in cancer therapy

A mathematical model for pancreatic cancer during intraepithelial neoplasia

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