P53 Expression in Esophageal Dysplasia - A Possible Biomarker for Carcinogenesis of Esophageal Squamous-Cell Carcinoma

Maruyama, Koji; Shiozaki, Hitoshi; Shimaya, K; Inoue, M; Iwazawa, Takashi; Matsui, Saki; Mori, Toru

doi:10.3892/ijo.4.5.1061

Cited by 3 publications

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“…For example, a long‐term follow‐up study of patients with oesophageal dysplasia showed that 30% of the cases progressed to squamous cell carcinoma over a follow‐up period of 2.5– 6.5 years 3 . Possible molecular bases of this process have been examined and several abnormalities have been described in dysplasia, including genetic instability, DNA aneuploidy, loss of heterozygosity, mutation of the tumour suppressor gene p53 , and a high proliferating cell nuclear antigen (PCNA) index 4–10 . However, much remains to be clarified about the dysplasia–carcinoma sequence of the oesophagus.…”

Section: Introductionmentioning

confidence: 99%

Expression of cell cycle regulatory proteins in the multistep process of oesophageal carcinogenesis: stepwise over‐expression of cyclin E and p53, reduction of p21^WAF1/CIP1 and dysregulation of cyclin D1 and p27^KIP1

2001

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Cell cycle regulatory proteins, cyclin E, p53 and p21 show stepwise over-expression or reduction with progression of oesophageal carcinogenesis, correlating with the increased cell proliferation observed with Ki67 labelling. We conclude that immunohistochemical analysis for p27, p53 and Ki67 is practically useful for the discrimination between low-grade dysplasia and reactive change. Cyclin D1, cyclin E, p27 and p53 help to distinguish high-grade dysplasia from mucosal invasive carcinoma.

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Section: Introductionmentioning

confidence: 99%

Expression of cell cycle regulatory proteins in the multistep process of oesophageal carcinogenesis: stepwise over‐expression of cyclin E and p53, reduction of p21^WAF1/CIP1 and dysregulation of cyclin D1 and p27^KIP1

2001

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“…Expression of p53 has been studied immunohistochemically in a number of neoplasms [6,17,27,39,46,48] where a good correlation between p53 protein expression and tumour stage has been shown. These reports comprise observations obtained in colorectal, head and neck, lung, urinary bladder, gastric, oesophageal and ovarian cancers [18,26,35,41,48,52].…”

Section: Introductionmentioning

confidence: 99%

Elevated content of p53 protein in the absence of p53 gene mutations as a possible prognostic marker for human renal cell tumors

Chemeris

Rempel

Bannasch

et al. 1995

Vichows Archiv A Pathol Anat

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p53 tumour suppressor gene expression was estimated immunohistochemically using DO-1 monoclonal antibody (recognising both wild-type and mutant p53 in 88 human renal tumours. Single strand conformation polymorphism (SSCP) analysis of possible mutations within exons 4-8 of the p53 gene was performed in 29 of the tumours (mostly immunostaining-positive cases). Obviously elevated p53 content was detected with DO-1 antibody in chromophobic cell carcinomas and most clear/chromophilic cell tumours (in chromophilic cell populations). In contrast, clear cell carcinomas demonstrated either complete absence of p53 expression or the presence of single immunopositive nuclei. Oncocytomas were completely negative. Additional immunostaining of the positive samples with mutant p53-specific Pab240 monoclonal antibody failed to detect immunopositive material. No p53 mutation was found in any of the samples analysed by SSCP. Our results suggest that the elevated p53 content in human renal cell carcinomas does not result from gene mutation and the p53 gene alterations are probably not an important mechanism in the development of human renal cell carcinomas. Accumulation of the wild-type p53 protein may be a useful prognostic marker indicating neoplastic progression malignancy.

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Study on Multiple Primary Cancer Associated with Esophageal Cancer

Emoto

Yamada

Watanabe

et al. 2001

JJCS

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P53 Expression in Esophageal Dysplasia - A Possible Biomarker for Carcinogenesis of Esophageal Squamous-Cell Carcinoma

Cited by 3 publications

References 0 publications

Expression of cell cycle regulatory proteins in the multistep process of oesophageal carcinogenesis: stepwise over‐expression of cyclin E and p53, reduction of p21^WAF1/CIP1 and dysregulation of cyclin D1 and p27^KIP1

Expression of cell cycle regulatory proteins in the multistep process of oesophageal carcinogenesis: stepwise over‐expression of cyclin E and p53, reduction of p21^WAF1/CIP1 and dysregulation of cyclin D1 and p27^KIP1

Elevated content of p53 protein in the absence of p53 gene mutations as a possible prognostic marker for human renal cell tumors

Study on Multiple Primary Cancer Associated with Esophageal Cancer

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P53 Expression in Esophageal Dysplasia - A Possible Biomarker for Carcinogenesis of Esophageal Squamous-Cell Carcinoma

Cited by 3 publications

References 0 publications

Expression of cell cycle regulatory proteins in the multistep process of oesophageal carcinogenesis: stepwise over‐expression of cyclin E and p53, reduction of p21WAF1/CIP1 and dysregulation of cyclin D1 and p27KIP1

Expression of cell cycle regulatory proteins in the multistep process of oesophageal carcinogenesis: stepwise over‐expression of cyclin E and p53, reduction of p21WAF1/CIP1 and dysregulation of cyclin D1 and p27KIP1

Elevated content of p53 protein in the absence of p53 gene mutations as a possible prognostic marker for human renal cell tumors

Study on Multiple Primary Cancer Associated with Esophageal Cancer

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Resources

About

Expression of cell cycle regulatory proteins in the multistep process of oesophageal carcinogenesis: stepwise over‐expression of cyclin E and p53, reduction of p21^WAF1/CIP1 and dysregulation of cyclin D1 and p27^KIP1

Expression of cell cycle regulatory proteins in the multistep process of oesophageal carcinogenesis: stepwise over‐expression of cyclin E and p53, reduction of p21^WAF1/CIP1 and dysregulation of cyclin D1 and p27^KIP1