p53 Expression in circulating lymphocytes of non-melanoma skin cancer patients from an arsenic contaminated region in Mexico. A pilot study

Salazar, Ana María; Calderón-Aranda, Emma S.; Cebrián, Mariano E.; Sordo, Monserrat; Bendesky, Andrés; Gómez-Muñoz, Arístides; Acosta‐Saavedra, Leonor C.; Ostrosky‐Wegman, Patricia

doi:10.1023/b:mcbi.0000007258.33942.f8

Cited by 18 publications

(10 citation statements)

References 42 publications

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“…The earliest known events affected by NaAsO 2 are the alterations on CD69 and CD25 in both CD4 + and CD8 + reported in this paper, and a reduction in IL-2 production [29,30]. In addition, alteration in transcription factors [11,54], damage in cytoskeleton [29], overexpression of p53 [7,10] and finally, chromosomal aberrations [19,55] led to a reduction in proliferation of T cells. The effect of NaAsO 2 on very early activation events of T lymphocytes remains to be established.…”

Section: Discussionmentioning

confidence: 57%

“…Several regions in China, Mexico, Argentina and India among others, are affected by arsenic contamination in drinking water [1]. Chronic exposure to arsenic has been related to the development of several types of cancer, cardiovascular disorders, diabetes, neuropathies and skin lesions [2][3][4][5][6][7]. Both arsenites (As 3+ ) and arsenates (As 5+ ) are the most common species found in contaminated drinking water [6,8], the former being the most toxic form of this element, due to its high reactivity with several cell components [6].…”

Section: Introductionmentioning

confidence: 99%

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Differential effect of sodium arsenite during the activation of human CD4+ and CD8+ T lymphocytes

Tenorio

Saavedra

2005

International Immunopharmacology

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Section: Discussionmentioning

confidence: 57%

Section: Introductionmentioning

confidence: 99%

Differential effect of sodium arsenite during the activation of human CD4+ and CD8+ T lymphocytes

Tenorio

Saavedra

2005

International Immunopharmacology

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“…Genotoxic effects were also observed through evaluation of micronucleus induction in cases of both environmental and occupational exposure in studies from Chile (Martinez et al, 2004; Paiva et al, 2008). Potentially as a result of As-induced DNA damage, levels of tumor suppressor protein p53 were elevated in high-exposure individuals (Salazar et al, 2004). Enhancing any genotoxicity of As would be the impairment of DNA repair capabilities that was observed by Andrew et al .…”

Section: Biological Markers Of Arsenic Exposure Metabolism Toxicmentioning

confidence: 99%

Arsenic exposure in Latin America: Biomarkers, risk assessments and related health effects

McClintock

Chen

Bundschuh

et al. 2012

Science of The Total Environment

157

106

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In Latin America, several regions have a long history of widespread arsenic (As) contamination from both natural and anthropological sources. Yet, relatively little is known about the extent of As exposure from drinking water and its related health consequences in these countries. It has been estimated that at least 4.5 million people in Latin America are chronically exposed to high levels of As (>50µg/L), some to as high as 2000 µg/L - 200 times higher than the World Health Organization (WHO) provisional standard for drinking water. We conducted a systematic review of 82 peer reviewed papers and reports to fully explore the current understanding of As exposure and its health effects, as well as the influence of genetic factors that modulate those effects in the populations of Latin America. Despite some methodological limitations, these studies suggested important links between high levels of chronic As exposure and elevated risks of numerous adverse health outcomes in Latin America - including internal and external cancers, reproductive outcomes, and childhood cognitive function. Several studies demonstrated genetic polymorphisms that influence susceptibility to these and other disease states through their modulation of As metabolism, with As methyltransferase (AS3MT), glutathione S-transferase (GST), and genes of one-carbon metabolism being specifically implicated. While the full extent and nature of the health burden are yet to be known in Latin America, these studies have significantly enriched knowledge of As toxicity and led to subsequent research. Targeted future studies will not only yield a better understanding of the public health impact of As in Latin America populations, but also allow for effective and timely mitigation efforts.

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“…This was confirmed by a HELIOS-1 multicentre case control study done by Berta Suarez, Gonzalo Lopez and Carmen Martinez, which analysed 1585 cases and found increased incidence of skin cancer in farmers, daily labourers and factory workers. [8][9][10] In this study ulcer was the commonest mode of presentation and was found in 54 (53.47%) cases. This was followed by UPF growth in 35 (34.65%) cases.…”

mentioning

confidence: 92%

Clinicopathological profile, diagnosis and treatment of skin cancers at a tertiary care center: a retrospective study

Jina¹,

Singh²,

Saini³

et al. 2017

Int Surg J

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INTRODUCTIONMalignant skin lesions have become increasingly prevalent over the past several years. In United States, approximately 5.4 million cases of non-melanoma skin cancers are treated in 2012.1 Skin cancer account for more than 40% of all malignancies. Majority of skin cancers are basal cell carcinoma (BCC), squamous cell carcinoma (SCC) and melanoma which account for more than 95% of total skin malignancies. 1The incidence in males in Delhi for malignant melanoma is 0.29% and 0.90% for other skin cancers. The incidence ABSTRACT Background: Majority of skin cancers are basal cell carcinoma, Squamous cell carcinoma and Malignant melanoma which account for more than 95% of total skin malignancies. There is an increase in incidence in India over some 10 years of period. This study was done for analysing clinicopathological profile of skin malignancies and association of human papilloma virus (HPV) in skin malignancies in Himalayan Institute of Medical Sciences (HIMS, Uttarakhand, India. Methods: It was a retrospective study done on 101 patients having malignant skin lesions attending the Department of Surgery at HIMS from October 2005 to October 2008 and given their consent. Results: Out of 101 patients, 68 had squamous cell carcinoma, 21 had basal cell carcinoma and 10 had malignant melanoma, prevalence is high in men of lower socioeconomic status (M:F) 1.9:1. The mean age was 54.50 years. Most of the patients were laborers, farmers and factory workers. Ulcers and ulceroproliferative growth were common mode of presentation. Most commonly associated risk factor was exposure to sunlight, the commonest location of skin cancer was face and scalp. Wide local excision was the commonest done procedure with closure of primary defect by SSG, fasciocutaneous or cutaneous flaps. No HPV association was seen. Conclusions: Skin cancers are quite common and their incidence has increased in last few decades, in this study we found that skin cancer were more common in males of lower socioeconomic status, probable cause was increased sun exposure and chemical exposure, in respect to females. Cancer could manifest in many forms but ulcers quite common, Squamous cell carcinoma outnumbered basal cell carcinoma, Wide local excision with skin grafts was main stay of treatment.

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p53 Expression in circulating lymphocytes of non-melanoma skin cancer patients from an arsenic contaminated region in Mexico. A pilot study

Cited by 18 publications

References 42 publications

Differential effect of sodium arsenite during the activation of human CD4+ and CD8+ T lymphocytes

Differential effect of sodium arsenite during the activation of human CD4+ and CD8+ T lymphocytes

Arsenic exposure in Latin America: Biomarkers, risk assessments and related health effects

Clinicopathological profile, diagnosis and treatment of skin cancers at a tertiary care center: a retrospective study

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