p53 expression in breast cancer predicts tumors with low probability of non‐sentinel nodes infiltration

Vernet-Tomas, M.; Baños, Núria; Sabadell, Dolors; Corominas, Josep M.; Mestre-Fusco, Antoni; Suárez-Piñera, Marina; Carreras, Ramón

doi:10.1111/jog.12670

Cited by 7 publications

(5 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We concluded that a p53 positivity burden together with a high histological grade were associated with a low axillary tumor load. This conclusion is consistent with the results of our previous study . Positive p53 breast cancers, although aggressive, could explain low axillary involvement because they would mainly start hematological dissemination during tumor growth .…”

Section: Discussionsupporting

confidence: 93%

“…This conclusion is consistent with the results of our previous study. 18 Positive p53 breast cancers, although aggressive, could explain low axillary involvement because they would mainly start hematological dissemination during tumor growth. 19 In the present study, significant differences were observed in bivariate analysis but not in multivariate analysis.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Imaging and pathology features to predict axillary tumor load in breast cancer

Bosch-Nicolau

Gamero

Rodríguez-Arana

et al. 2017

J of Obstet and Gynaecol

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Imaging and pathology features to predict axillary tumor load in breast cancer

Bosch-Nicolau

Gamero

Rodríguez-Arana

et al. 2017

J of Obstet and Gynaecol

Self Cite

View full text Add to dashboard Cite

show abstract

“…We also found that higher EpCAM expression was correlated with high Ki67 expression and low p53 expression. It is well known that p53 is the tumor suppressor and has many mechanisms of anticancer function, and plays a role in apoptosis, genomic stability, and inhibition of angiogenesis [ 17 , 18 ]. Ki-67 is a tumor marker that is found in growing, dividing cells.…”

Section: Resultsmentioning

confidence: 99%

By inhibiting Ras/Raf/ERK and MMP-9, knockdown of EpCAM inhibits breast cancer cell growth and metastasis

Gao

Yang

et al. 2015

Oncotarget

View full text Add to dashboard Cite

Epithelial cell adhesion molecule (EpCAM) is a type I transmembrane protein that is expressed in the majority of normal epithelial tissues and is overexpressed in most epithelial cancers including breast cancer, where it plays an important role in cancer progression. However, the mechanism by which EpCAM promotes the progression of breast cancer is not understood. In this study, we found that EpCAM expression was increased in tumor tissue from breast cancer patients compared to healthy patients. Overexpression of EpCAM in breast cancer cells enhanced tumor cell growth in vitro and increased invasiveness, whereas small interfering RNA-mediated silencing of EpCAM (si-EpCAM) had the opposite effect. EpCAM knockdown led to decreased phosphorylation of Raf and ERK, suppression of malignant behavior of breast cancer cells, and inhibition of the Ras/Raf/ERK signaling pathway. Furthermore, si-EpCAM-mediated invasion and metastasis of breast carcinoma cells required the downregulation of matrix metalloproteinase-9 (MMP-9) through inhibition of this signaling pathway. In conclusion, our data show that knockdown of EpCAM can inhibition breast cancer cell growth and metastasis via inhibition of the Ras/Raf/ERK signaling pathway and MMP-9.

show abstract

“…The prognostic and predictive value of p53 expression in axillary lymph node metastasis in patients with breast carcinoma needs to be further evaluated in larger trials with longer follow-up (Arun et al, 2003). A number of studies reported that the expression of p53 had direct correlation with tumor size (Osanai et al, 2005), histological grade (Qing et al, 2014;Osanai et al, 2005;Sirvent et al, 1995;Bertheau et al, 1998), nuclear grade (Jasar et al, 2015, lymph-vascular invasion (Osanai et al, 2005), the proliferation index Ki67 (Jasar et al, 2015) and ER status (Osanai et al, 2005;Li et al, 2015), but other studies showed that the expression of p53 had inverse correlation with histological grade (el-A Helal et al, 2000), lymph-vascular invasion (Jasar et al, 2015), non-sentinel lymph node invasion (Vernet et al, 2015) and estrogen (Sirvent et al, 1995) and progesterone receptors (Sirvent et al, 1995;Bertheau et al, 1998). Also, a number of studies reported that there was no significant correlation between the expression of p53 and age (Qing et al, 2014), clinical stage (Qing et al, 2014), or lymph node metastasis (Sirvent et al, 1995;Sjostrom-Mattson et al, 2009;Qing et al, 2014) in the BC.…”

Section: Discussionmentioning

confidence: 99%

Expression of p53 Breast Cancer in Kurdish Women in the West of Iran: a Reverse Correlation with Lymph Node Metastasis

Payandeh¹,

Sadeghi²,

Sadeghi³

et al. 2016

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Background: In breast cancer (BC), it has been suggested that nuclear overexpression of p53 protein might be an indicator of poor prognosis. The aim of the current study was to evaluate the expression of p53 BC in Kurdish women from the West of Iran and its correlation with other clinicopathology figures. Materials and Methods: In the present retrospective study, 231 patients were investigated for estrogen receptor (ER) and progesterone receptor (PR) positivity, defined as ≥10% positive tumor cells with nuclear staining. A binary logistic regression model was selected using Akaike Information Criteria (AIC) in stepwise selection for determination of important factors. Results: ER, PR, the human epidermal growth factor receptor 2 (HER2) and p53 were positive in 58.4%, 55.4%, 59.7% and 45% of cases, respectively. Ki67 index was divided into two groups: 54.5% had Ki67<20% and 45.5% had Ki67 ≥20%. Of 214 patients, 137(64%) had lymph node metastasis and of 186 patients, 122(65.6%) had vascular invasion. Binary logistic regression analysis showed that there was inverse significant correlation between lymph node metastasis (P=0.008, OR 0.120 and 95%CI 0.025-0.574), ER status (P=0.006, OR 0.080, 95%CI 0.014-0.477) and a direct correlation between HER2 (P=005, OR 3.047, 95%CI 1.407-6.599) with the expression of p53. Conclusions: As in a number of studies, expression of p53 had a inverse correlation with lymph node metastasis and ER status and also a direct correlation with HER2 status. Also, p53-positivity is more likely in triple negative BC compared to other subtypes.

show abstract

p53 expression in breast cancer predicts tumors with low probability of non‐sentinel nodes infiltration

Abstract: p53 expression in breast cancer was highly predictive of non-sentinel lymph node negativity in our study. New studies should evaluate if it would be useful to add p53 expression to other existing predictive tools.

Cited by 7 publications

References 25 publications

Imaging and pathology features to predict axillary tumor load in breast cancer

Imaging and pathology features to predict axillary tumor load in breast cancer

By inhibiting Ras/Raf/ERK and MMP-9, knockdown of EpCAM inhibits breast cancer cell growth and metastasis

Expression of p53 Breast Cancer in Kurdish Women in the West of Iran: a Reverse Correlation with Lymph Node Metastasis

Contact Info

Product

Resources

About