p53 Expression and Environmental Tobacco Smoke Exposure in Feline Oral Squamous Cell Carcinoma

Snyder, Laura A.; Bertone, Elizabeth R.; Jakowski, R. M.; Dooner, Mark S.; Jennings-Ritchie, J.; Moore, A. S.

doi:10.1354/vp.41-3-209

“…6,8,73,103,168 Environmental tobacco smoke (ETS) exposure, flea collar use, canned foods, and papillomavirus infection have been implicated as being potentially involved in SCC development in cats. 9,103,126,182 Adjacent bone invasion, lymph node metastasis, and spontaneous recurrence are frequent complications in this cancer. 126,127 At the time of diagnosis, the disease is often in the late stages with extensive bone invasion.…”

Section: Animal Modelsmentioning

confidence: 99%

“…9,103,126,182 Adjacent bone invasion, lymph node metastasis, and spontaneous recurrence are frequent complications in this cancer. 126,127 At the time of diagnosis, the disease is often in the late stages with extensive bone invasion. Spontaneous HNSCC in cats is a potential valuable model for translational research on novel drug, genetic, nanoparticle, and interventional therapies using clinical trials of client-owned cats in the clinical veterinary setting.…”

Section: Animal Modelsmentioning

confidence: 99%

Animal Models of Bone Metastasis

Simmons

¹

,

Hildreth

²

,

Supsavhad

³

et al. 2015

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Bone is one of the most common sites of cancer metastasis in humans and is a significant source of morbidity and mortality. Bone metastases are considered incurable and result in pain, pathologic fracture, and decreased quality of life. Animal models of skeletal metastases are essential to improve the understanding of the molecular pathways of cancer metastasis and growth in bone and to develop new therapies to inhibit and prevent bone metastases. The ideal animal model should be clinically relevant, reproducible, and representative of human disease. Currently, an ideal model does not exist; however, understanding the strengths and weaknesses of the available models will lead to proper study design and successful cancer research. This review provides an overview of the current in vivo animal models used in the study of skeletal metastases or local tumor invasion into bone and focuses on mammary and prostate cancer, lymphoma, multiple myeloma, head and neck squamous cell carcinoma, and miscellaneous tumors that metastasize to bone.

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“…6,8,73,103,168 Environmental tobacco smoke (ETS) exposure, flea collar use, canned foods, and papillomavirus infection have been implicated as being potentially involved in SCC development in cats. 9,103,126,182 Adjacent bone invasion, lymph node metastasis, and spontaneous recurrence are frequent complications in this cancer. 126,127 At the time of diagnosis, the disease is often in the late stages with extensive bone invasion.…”

Section: Yd-39mentioning

confidence: 99%

“…9,103,126,182 Adjacent bone invasion, lymph node metastasis, and spontaneous recurrence are frequent complications in this cancer. 126,127 At the time of diagnosis, the disease is often in the late stages with extensive bone invasion. Spontaneous HNSCC in cats is a potential valuable model for translational research on novel drug, genetic, nanoparticle, and interventional therapies using clinical trials of client-owned cats in the clinical veterinary setting.…”

Section: Yd-39mentioning

confidence: 99%

Animal Models of Bone Metastasis

Rosol

¹

,

Tannehill-Gregg²,

Corn³

et al. 2004

Cancer Treatment and Research

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Bone is one of the most common sites of cancer metastasis in humans and is a significant source of morbidity and mortality. Bone metastases are considered incurable and result in pain, pathologic fracture, and decreased quality of life. Animal models of skeletal metastases are essential to improve the understanding of the molecular pathways of cancer metastasis and growth in bone and to develop new therapies to inhibit and prevent bone metastases. The ideal animal model should be clinically relevant, reproducible, and representative of human disease. Currently, an ideal model does not exist; however, understanding the strengths and weaknesses of the available models will lead to proper study design and successful cancer research. This review provides an overview of the current in vivo animal models used in the study of skeletal metastases or local tumor invasion into bone and focuses on mammary and prostate cancer, lymphoma, multiple myeloma, head and neck squamous cell carcinoma, and miscellaneous tumors that metastasize to bone. Keywordscancer; mammary; prostate; squamous cell carcinoma; dog; cat; parathyroid hormone; related protein; osteoblastic Cancer is the second leading cause of death in the United States, behind only heart disease. Death in patients with cancer is often due to metastasis, and one of the most common sites is bone. 109 Skeletal metastases are frequent in patients with breast, prostate, and lung cancer but also occur in other tumors such as myeloma, thyroid and renal cancer, lymphoma, Ewing sarcoma, and infrequently in other cancers. 110,146 Bone metastases can result in osteolytic (bone-resorbing) or osteoblastic (bone-forming) metastases that can cause pain, pathologic fractures, and mortality. 108,163 The general pathogenesis of bone metastasis involves proliferation of the primary neoplasm, local tissue invasion, intravasation into blood vessels, extravasation into the bone marrow, a Reprints and permission: sagepub.com/journalsPermissions.nav Corresponding Author: T. J. Rosol, Department of Veterinary Biosciences, The Ohio State University, 1925 Coffey Rd., Columbus, OH 43210, USA. rosol.1@osu.edu. Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. HHS Public AccessAuthor manuscript Vet Pathol. Author manuscript; available in PMC 2015 September 01. Author Manuscript Author ManuscriptAuthor ManuscriptAuthor Manuscript variable time of tumor cell dormancy, proliferation in bone, and modification of the bone microenvironment. 30 The current hypothesis for preferential localization of cancer cells in bone is the "seed and soil" hypothesis of Paget, 95 which states that neoplastic cells (seeds) grow or proliferate only in a suitable soil, such as the bone marrow. This hypothesis has remained intact for over 100 years; however, now there is a deeper appreciation for the important role that the bone marrow microenvironment plays in metastasis. The metastatic tumor...

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“…Pug) and middlenosed breeds (e.g. Husky), and malignant lymphoma and squamous cell carcinoma in cats (Bertone et al 2002;Knottenbelt et al 2012;McNiel et al 2007;Reif et al 1998;Snyder et al 2004). Additionally, secondhand smoke exposure has been shown to be associated with atopic dermatitis (Ka et al 2014) and contribute to airway limitation in dogs (Yamaya et al 2014).…”

Section: Veterinary Outreachmentioning

confidence: 99%