“P53 Codon 72 Single Base Substitution in Viral Hepatitis C and Hepatocarcinoma Incidences”

Abstract

Viral infection with hepatitis C virus (HCV) has a high propensity in becoming chronic and it is the major cause of hepatocellular carcinoma (HCC) worldwide. This review was basically established to illustrate the putative role of the P53 gene Arg72Pro polymorphism on various cancer models and viral infections, focusing on HCV and HCC incidences. Authors studied the 72 G/C single base substitution of P53 gene at codon 72 using various polymorphic techniques. Intriguingly, authors investigated that the P53 codon 72 plays a crucial role as risk factor in several cancer models. Others found that there is no association between codon 72 genotypes and HCV disease severity or liver cancer. Moreover, the lack of a significant relationship between this polymorphism and risk of HCC shows that it does not predispose towards hepatocarcinogenesis and the frequent loss of the proline allele in HCV-associated carcinogenesis of the liver plays some critical role in hepatocarcinogenesis. Amazingly, there is a significant correlation between male homozygotes for P53 72Pro with HCV type 1b infection. However, there was no significant difference between the P53 polymorphism and HCV genotypes 2a and 2b. It was concluded that the P53 gene polymorphism at codon 72 has been investigated as potential risk factor in several cancer models and HCV infections.

Both p53 codon 72 Arg/Arg and pro/Arg genotypes in glioblastoma multiforme are associated with a better prognosis in bevacizumab treatment

“…Nonetheless, more and more meta-analysis evidence obtained by pooling all the currently available case-control studies to estimate the effect and distribution of p53 codon 72 Arg/Pro polymorphism on cancer susceptibility has indicated that the polymorphism is not associated with overall cancer odds in several populations, including Iranian [ 41 ] and Chinese [ 42 ] colorectal cancer patients [ 43 ]. However, others studies have indicated the opposite, that is, that the polymorphism is associated with increased risk of several malignancies associated with viral infections, including in Caucasian (prostate cancer) [ 44 ], European (high-grade glioma; Pro 72) [ 45 ], Indian (cervical cancer) [ 46 ], Chinese (cervical cancer) [ 47 ], and Japanese (hepatocellular carcinoma) populations [ 48 ], implying that important ethnic and tumor type differences may exist regarding the cancer susceptibility of p53 codon 72 polymorphisms. Although our data could not show whether a given p53 codon 72 polymorphism is a risk factor, such polymorphisms may have an influence on GBM susceptibility in combination with certain other elements.…”

Human TP53 gene polymorphisms among patients with Hepatocellular carcinoma and chronic hepatitis B infection in Kenya

“…Other studies comparing acute hepatitis C and HCC have not found any association between codon 72 polymorphism and disease severity or HCC(Eskander et al, 2014;Hu et al, 2014). The inconsistency in association and prevalence observed could be attributable to geographical, environmental or ethnic differences in the studied population.…”

Polymorphism studies on microRNA targetome of thalassemia

“…Moreover, the understanding of the phenotype-genotype correlation is difficult due to modifying factors in thalassemia [ 2 ]. Several studies have been demonstrated that the occurring variation in some genes, such as HBA1, HBA2, HBB, HBG1, HBG2, BCL11A, COL1A1, CAT and GST genes can moderate the severity of thalassemia [ 16 , 17 , 18 , 19 , 20 ]. Recently, several studies have evaluated the effect of 3'-UTR SNPs on gene expression.…”

“…In this study, the genes related to the severity of thalassemia intermedia (TI) were extracted from known literatures [ 16 , 17 , 18 , 19 , 20 ]and the mRNA expression profile and molecular functions of these genes were obtained. Then, miRNA target site SNPs were predicted by in silico analysis.…”