p53 codon 72 genotypes in HPV infection and cervical disease

The p53 R72P polymorphism does not influence cervical cancer development in a portuguese population: A study in exfoliated cervical cells

“…Storey et al [1998] showed that women homozygous for the Arg allele were more susceptible to develop cervical cancer than Arg/Pro heterozygous or Pro/Pro homozygous women and concluded therefore that this polymorphism might be involved in cervical carcinogenesis. However, our study shows that there is no increased risk concerning Arg/Arg genotype in the different cytological categories (P ¼ 0.336), in agreement with the most recently studies including those that used blood [Hayes et al, 1998;Kim et al, 2001;Humbey et al, 2002;Santos et al, 2005] or exfoliated cervical cells [Klaes et al, 1999;Tachezy et al, 1999;Tenti et al, 2000;Abba et al, 2003].…”

“…We analyzed in the Portuguese population, the influence of p53 R72P polymorphism among negative and positive cases for High-Risk HPV, specifically for HPV16, which is the most prevalent high-risk type High-Risk HPV [zur Hausen, 1996;Medeiros et al, 2005] and in accordance with other reports [Abba et al, 2003;Santos et al, 2005], we have not found significant differences (P ¼ 0.794 and P ¼ 0.877 respectively). These results have shown that in our population there is no association between the p53 codon 72 genotypes and HPV status.…”

“…Storey et al [1998] proposed that the protein containing an arginine residue was more efficiently targeted for degradation by the HPV16 E6 [Dokianakis and Spandidos, 2000;Pegoraro et al, 2002]. However, the role of this polymorphism remains controversial, since recently published studies do not confirm this association between R72P polymorphism and cervical cancer [Abba et al, 2003;Mitra et al, 2005;Santos et al, 2005;Sousa et al, 2007].…”

601 p53 codon 72 polymorphism in basal cell carcinoma of skin

“…14 However, the issue is still controversial in some other types of cancers and in some ethnic groups. [15][16][17][18][19][20] This study was undertaken to investigate the association of p53 codon 72 polymorphism with BCC in southern Iranian patients.…”

Identifying the combination of genetic factors that determine susceptibility to cervical cancer

“…Some research [9] has implicated the proline/argine polymorphism of the codon 72 of the tumor-suppressor gene p53 in the development of cervical cancer, based on the observation that the p53 protein is more efficiently inactivated by the E6 oncoprotein of HPV in p53 arginine than by its proline isoform [10]. However, other research presents evidence refuting this relation [11]- [13]. Other SNPs, such as those on genes MCP, IL4, IL10, Smad 2, Smad 4, MMP, and CAV-1, also may be related to cervical cancer [14]- [18].…”