p53 Arg72Pro Polymorphism Predicts Survival Outcome in Lung Cancer Patients in Indian Population

Sreeja, Leelakumari; Syamala, Vani; Raveendran, Praveenkumar B.; Sarojam, Santhi; Madhavan, Jayaprakash; Ankathil, Ravindran

doi:10.1080/07357900701638459

Cited by 34 publications

(27 citation statements)

References 22 publications

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“…The Arg/Pro polymorphism at codon 72 is one of the ten polymorphisms that have been detected in human p53 so far (30). Sreeja et al (31) have shown that the Pro allele at codon 72 may alter the enzyme activity of p53. The Pro allele seems to favour p53 binding to p73, a p53 homologue and transcription factor of some p53 target genes, which may lead to alterations in the activation of some p53-interacting genes (32).…”

Section: Discussionmentioning

confidence: 99%

Association Between XRCC1 ARG399GLN and P53 ARG72PRO Polymorphisms and the Risk of Gastric and Colorectal Cancer in Turkish Population

Karahalıl

Karakaya

Engin

2011

Archives of Industrial Hygiene and Toxicology

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Gastric cancer is one of the most common cancers of the gastrointestinal system, and its overall fi ve-year survival rate is still 15 % to 20 %, as it can mostly be diagnosed at an advanced stage. On the other hand, although colorectal cancer has a rather good prognosis, mortality is one half that of the incidence. As carcinogenesis is believed to involve reactive radicals that cause DNA adduct formation, impaired repair activity, and weakened tumour suppression, it would help to understand the role of the polymorphisms of nucleotide excision repair enzyme XRCC1 and of tumour suppressor gene p53 in gastric and colorectal cancers. Our study included 94 gastric cancer patients, 96 colorectal cancer patients, and 108 cancer-free individuals as control with the aim to see if there was an association between XRCC1 Arg399Gln and p53 Arg72Pro polymorphisms and cancer susceptibility. DNA was extracted from peripheral blood cells and genotypes were determined using the polymerase chain reaction-restriction fragment length polymorphism. Polymorphism p53 Arg72Pro was not associated with either gastric or colorectal carcinoma, while XRCC1 Arg399Gln was not associated with the increased risk of colorectal cancer. However, XRCC1 homozygous Gln allele at codon 399 was associated with 2.54 times higher risk of gastric cancer.

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Section: Discussionmentioning

confidence: 99%

Association Between XRCC1 ARG399GLN and P53 ARG72PRO Polymorphisms and the Risk of Gastric and Colorectal Cancer in Turkish Population

Karahalıl

Karakaya

Engin

2011

Archives of Industrial Hygiene and Toxicology

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“…Genetic studies of lung cancer have led to the discovery of hundreds of associated genes, such as those encoding p53, BRCA1, and serine/threonine kinase (Reguart et al, 2008;Sreeja et al, 2008;Strazisar et al, 2009), which can partly explain the genetic risk factors. Several lung cancer susceptibility loci have recently been identified in genome-wide association studies (Easton and Eeles, 2008; Thomas et al, 2008;Boezen, 2009;Caporaso et al, 2009;Landi et al, 2009;Chung et al, 2010;Hsiung et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Multiple variants of TERT and CLPTM1L constitute risk factors for lung adenocarcinoma

Chen¹,

Cai²,

Chen³

et al. 2012

Genet. Mol. Res.

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ABSTRACT. Recent studies have shown that 5p15.33 is one of the chromosomal regions that is most consistently altered in lung cancer; common variants that are located in this region have been genotyped in various populations. However, the genetic contribution of these variants to carcinogenesis is relatively unknown. A clinic-based case-control study in Shanghai was undertaken on 196 patients with lung cancer and 229 healthy individuals. TERT rs2736100 and CLPTM1L rs401681 and rs402710 were genotyped using the ABI TaqMan Allelic Discrimination assay. For rs2736100, the G variant and the GG genotype were more frequent, whereas the TT genotype was less frequent in patients with lung adenocarcinoma than in controls. The CT genotype at rs401681 was more common and the TT genotype was rare in patients, and the differences were significant between lung adenocarcinoma patients and controls. This was also true for rs402710. Moreover, the frequency of Variants of TERT and CLPTM1L in lung cancer the GGCTCT haplotype was higher and the TTTTTT frequency was lower in patients, especially those with lung adenocarcinoma. Aberrant linkage disequilibrium among the three SNPs was found in patients with lung adenocarcinoma. We conclude that multiple variants at 5p15.33 contribute to susceptibility to lung adenocarcinoma.

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“…Recently, genetic studies, in particular genome-wide association studies (GWAS), have led to the discovery of several chromosomal regions that contain genes associated with lung cancer risk, including those encoding p53, BRCA1, and serine/threonine kinase (Reguart et al, 2008;Sreeja et al, 2008;Strazisar et al, 2009). In addition, 5p15.33 was recently identified as a susceptibility region for lung cancer, where the telomerase reverse transcriptase (TERT) and cleft lip and palate transmembrane 1-like (CLPTM1L) genes are located (Kang et al, 2008;McKay et al, 2008;Wang et al, 2008;Jin et al, 2009;Rafnar et al, 2009;Zienolddiny et al, 2009;Hsiung et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Decreased risk of developing lung cancer in subjects carrying the CLPTM1L rs401681 (G>A) polymorphism: evidence from a meta-analysis

Zhang¹,

Zhang²,

Zhang³

et al. 2014

Genet. Mol. Res.

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ABSTRACT.A genome-wide association study revealed that a single nucleotide polymorphism, CLPTM1L -rs401681 (G>A), located at the 5p15.33 locus was significantly associated with increased risk of various cancers; however, its association with lung cancer is currently inconclusive. In order to explore the relationship between this polymorphism and lung cancer risk more precisely, we performed a meta-analysis of eight eligible studies involving 9935 cases and 11,261 controls. The pooled odds ratio (OR) and the 95% confidence interval (CI) were calculated using a fixedor random-effect models. Results indicated that this polymorphism was significantly associated with lung cancer risk in all genetic models (GA ). An analysis stratified by ethnicity and source of controls revealed a significantly decreased risk among European groups and population-based studies in all genetic models, and among Asian populations only in the dominant model comparison. Additionally, in a subgroup analysis by histology type, the CLPTM1L rs401681 polymorphism was found to significantly decrease the risks of both adenocarcinoma and squamous cell carcinoma of the lung in all genetic models. In conclusion, our study indicated that the CLPTM1L -rs401681 (G>A) polymorphism was significantly associated with decreased lung cancer risk, especially among European populations. Due to some minor limitations, our findings should be confirmed in further studies.

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p53 Arg72Pro Polymorphism Predicts Survival Outcome in Lung Cancer Patients in Indian Population

Cited by 34 publications

References 22 publications

Association Between XRCC1 ARG399GLN and P53 ARG72PRO Polymorphisms and the Risk of Gastric and Colorectal Cancer in Turkish Population

Association Between XRCC1 ARG399GLN and P53 ARG72PRO Polymorphisms and the Risk of Gastric and Colorectal Cancer in Turkish Population

Multiple variants of TERT and CLPTM1L constitute risk factors for lung adenocarcinoma

Decreased risk of developing lung cancer in subjects carrying the CLPTM1L rs401681 (G>A) polymorphism: evidence from a meta-analysis

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