Abstract:INTRODUCTION2.1. The tumour suppressor p53 2.1.1. p53 protein structure 2.1.2. Biological functions of p53 Cell cycle arrest Senescence Apoptosis 2.1.3. Accumulation and activation of p53 by stress Stabilization of p53 Activation and sequence-specific DNA binding of p53 The mechanisms of p53-activated transcription on the promoter of target genes Regulation of p21 transcription by p53
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