Abstract:Rationale and HypothesisHIV-1-seropositive individuals receiving highly active antiretroviral therapy (HAART) have an increased incidence of chronic obstructive pulmonary disease (COPD), independent of smoking history. Although HIV-1 infection is associated with impaired redox homeostasis and increased pro-inflammatory cytokine expression in the lungs despite HAART, the mechanisms driving HIV-1-associated COPD are poorly understood. Free HIV-1 envelope glycoprotein gp120 is detectable in bronchoalveolar lavage… Show more
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