Abstract:The aging heart undergoes structural and functional changes that are reminiscent of the failing heart. We hypothesized that aging may increase cardiac vulnerability to develop heart failure in response to mechanical overload. To test this hypothesis, we subjected mice to pressure overload by transverse aortic constriction (TAC) or myocardial infarction (MI) at 3, 12 and 24 months of age. Eight weeks after TAC or MI, left ventricular (LV) geometry, LV function and LV weight were determined. Aging minimally affe… Show more
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