P468: Detection and Characterization of Residual Leukemic Cells in Childhood Acute Myeloid Leukemia Using Targeted Deep Sequencing and Single Cell Multi-Omics

Abstract

In children with acute myeloid leukemia (AML), treatment intensification based on measurable residual disease (MRD) detected by multiparameter flow cytometry (MFC) shows promising results. However, a substantial proportion of patients with no detectable MRD by MFC relapse, indicating that more sensitive methods for MRD analysis are needed.