P435Extracellular vesicles mediate cardioprotection exerted by remote ischemic preconditioning in rats

Baranyai, Tamás; Giricz, Zoltán; Varga, ZV; Sipos, Péter; Pálóczi, Krisztina; Kittel, Ágnes; Buzás, Edit I.; Ferdinándy, Péter

doi:10.1093/cvr/cvu091.114

Cited by 2 publications

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“…When exosomes were removed from the coronary effluent of the IPre hearts by centrifugation, the protection was lost. 114 In addition, immunoblot analysis using heat shock protein 60 as an exosome marker revealed that IPre increases the exosomes production of the heart. 114 In another study, serum was collected from rats receiving RIP by bilateral femoral artery I/R, and an exosome-enriched fraction of the serum increased the tolerance of HL-1 cardiomyocytes to hypoxia/reoxygenation, but enriched serum from non-RIP rats was not protective.…”

Section: Introductionmentioning

confidence: 99%

“…114 In addition, immunoblot analysis using heat shock protein 60 as an exosome marker revealed that IPre increases the exosomes production of the heart. 114 In another study, serum was collected from rats receiving RIP by bilateral femoral artery I/R, and an exosome-enriched fraction of the serum increased the tolerance of HL-1 cardiomyocytes to hypoxia/reoxygenation, but enriched serum from non-RIP rats was not protective. 115 Intramyocardial injection of concentrated exosomes from hind limb RIP rats decreased in the IS–AAR ratio and improved pumping function of the heart while that from non-RIP rats did not.…”

Section: Introductionmentioning

confidence: 99%

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A Review of Humoral Factors in Remote Preconditioning of the Heart

Tsibulnikov

Маслов

Gorbunov

et al. 2019

J Cardiovasc Pharmacol Ther

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A humoral mechanism of cardioprotection by remote ischemic preconditioning (RIP) has been clearly demonstrated in various models of ischemia–reperfusion including upper and lower extremities, liver, and the mesenteric and renal arteries. A wide range of humoral factors for RIP have been proposed including hydrophobic peptides, opioid peptides, adenosine, prostanoids, endovanilloids, endocannabinoids, calcitonin gene-related peptide, leukotrienes, noradrenaline, adrenomedullin, erythropoietin, apolipoprotein, A-I glucagon-like peptide-1, interleukin 10, stromal cell-derived factor 1, and microRNAs. Virtually, all of the components of ischemic preconditioning’s signaling pathway such as nitric oxide synthase, protein kinase C, redox signaling, PI3-kinase/Akt, glycogen synthase kinase β, ERK1/2, mitoKATP channels, Connexin 43, and STAT were all found to play a role. The signaling pattern also depends on which remote vascular bed was subjected to ischemia and on the time between applying the rip and myocardial ischemia occurs. Because there is convincing evidence for many seemingly diverse humoral components in RIP, the most likely explanation is that the overall mechanism is complex like that seen in ischemic preconditioning where multiple components are both in series and in parallel and interact with each other. Inhibition of any single component in the right circumstance may block the resulting protective effect, and selectively activating that component may trigger the protection. Identifying the humoral factors responsible for RIP might be useful in developing drugs that confer RIP’s protection in a more comfortable and reliable manner.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Review of Humoral Factors in Remote Preconditioning of the Heart

Tsibulnikov

Маслов

Gorbunov

et al. 2019

J Cardiovasc Pharmacol Ther

View full text Add to dashboard Cite

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Exosomes: promising sacks for treating ischemic heart disease?

Chen

Yang

2017

American Journal of Physiology-Heart and Circulatory Physiology

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Ischemic heart disease(IHD) is the leading cause of death worldwide. Despite the development of continuously improving therapeutic strategies, morbidity and mortality of patients with IHD remain relatively high. Exosomes are a subpopulation of vesicles that are universally recognized as major mediators in intercellular communication. Numerous preclinical studies have shown that these tiny vesicles were protective in IHD, through such actions as alleviating myocardial ischemia-reperfusion injury, promoting angiogenesis, inhibiting fibrosis, and facilitating cardiac regeneration. Our review focused on these beneficial exosome-mediated processes. In addition, we discuss in detail how to fully exploit the therapeutic potentials of exosomes in the field of IHD. Topics include identifying robust sources of exosomes, loading protective agents into exosomes, developing heart-specific exosomes, optimizing isolation methods, and translating the cardioprotective effects of exosomes into clinical practice. Finally, both the advantages and disadvantages of utilizing exosomes in clinical settings are addressed.

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P435Extracellular vesicles mediate cardioprotection exerted by remote ischemic preconditioning in rats

Cited by 2 publications

References 0 publications

A Review of Humoral Factors in Remote Preconditioning of the Heart

A Review of Humoral Factors in Remote Preconditioning of the Heart

Exosomes: promising sacks for treating ischemic heart disease?

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