P418 Predictive factors of surgery in the course of Crohn’s disease

Agar, K; Medhioub, M; Jardak, S; Hamzaoui, Lamine; Khsiba, A; Azzouz, Mohamed

doi:10.1093/ecco-jcc/jjx180.545

Cited by 2 publications

(2 citation statements)

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“…CDAI score > 287 and Mayo score > 8.5 achieved high sensitivity and specificity for the detection of surgical treatment. Similarly, Agar et al [16] reported that CDAI > 250 was independent predictive risk factors for subsequent surgery in CD.…”

Section: Discussionmentioning

confidence: 88%

“…In concordance with our findings, Nasir et al [15] documented that perianal disease and the NOD2 genotype were the only independent factors associated with the need for surgery. Agar et al [16] revealed that presence of complicated disease at diagnosis (intestinal stenosis, fistula) were independent predictive risk factors for subsequent surgery in CD.…”

Section: Discussionmentioning

confidence: 99%

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Predictors of surgical intervention in patients with inflammatory bowel disease (two-center study)

Megeed

Saleh

Mohamed³

et al. 2021

Egypt J Intern Med

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Background Sixty percent of Crohn’s disease (CD) patients require intestinal resection, and 20% of ulcerative colitis (UC) patients undergo proctocolectomy for medically refractory disease. Scarcity of literature about predictors for surgical intervention in inflammatory bowel disease (IBD) encouraged the conduction of this study to assess risk factors for surgical intervention in IBD patients. Results This cohort study included 80 Egyptian inflammatory bowel disease patients recruited from two medical centers. Patients were classified into two groups, 40 patients each, according to their need for surgical intervention to control inflammatory bowel disease. The two groups were compared regarding age of onset, type and location of disease, smoking, extraintestinal manifestations, perianal disease, granuloma, severity scores, stool calprotectin, complete blood count, erythrocyte sedimentation rate, C-reactive protein, and serum albumin at diagnosis for Crohn’s disease patients. Twelve ulcerative colitis and 28 Crohn’s disease patients required surgical intervention in the form of total colectomy (30%), fistulectomy (32.5%), resection anastomosis (17.5%) or abscess drainage (20%). Perianal disease, smoking, and disease severity scores showed high significant differences (P value < 0.001); disease type and presence of granuloma showed statistically significant difference (P value < 0.05) between both groups. But, patient age at onset, location of the disease or extraintestinal manifestation had no statistical significance (P value > 0.5). Surgical interventions were more likely to be needed in patients with higher stool calprotectin level, C-reactive protein, erythrocyte sedimentation rate, and lower serum albumin for Crohn’s disease patients (P value < 0.001 for each). Conclusion Smoking, perianal disease, higher severity scores, stool calprotectin, C-reactive protein, and erythrocyte sedimentation rate levels are predictors of surgical treatment.

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Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Predictors of surgical intervention in patients with inflammatory bowel disease (two-center study)

Megeed

Saleh

Mohamed³

et al. 2021

Egypt J Intern Med

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Predictors of non-response to ongoing conservative therapy in patients with inflammatory bowel disease

H. Babayeva,

I. Ibrahimli,

V. Holub

et al. 2024

Miscellaneous Considerations in Inflammatory Bowel Disease

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Crohn’s disease (CD) and ulcerative colitis (UC), which are part of the group of inflammatory bowel diseases (IBD), belong to the group of immune-mediated diseases and characterized by a chronic relapsing and chronically continuous course, which leads to serious exacerbations and consequences. Patients may undergo radical surgery, often for drug-resistant disease, and the costs associated with IBD are significant and rising. Over the past two decades, there has been a paradigm shift in the treatment of IBD. The therapeutic goal has shifted from eliminating symptoms alone to achieving combined (symptomatic and endoscopic) remission, which is associated with better outcomes, including a lower risk of relapse, need for corticosteroids, hospitalization, colectomy, and colorectal neoplasia. Despite all the successes, the trend of non-response to ongoing conservative therapy continues. Most studies monitor through endoscopic evaluation and a small number of laboratory tests. There is an important need to understand how noninvasive biomarkers can serve as accurate and reliable indicators for assessing inflammation and predictors of lack of response to therapy. The purpose of this publication is to provide evidence on the use of biomarkers to assess disease activity and predictors of non-response to therapy in patients with IBD.

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P418 Predictive factors of surgery in the course of Crohn’s disease

Cited by 2 publications

References 0 publications

Predictors of surgical intervention in patients with inflammatory bowel disease (two-center study)

Predictors of surgical intervention in patients with inflammatory bowel disease (two-center study)

Predictors of non-response to ongoing conservative therapy in patients with inflammatory bowel disease

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