P417 Nosocomial Clostridium difficile infection (CDI) incidence in two Spanish referral hospitals. Secular trend during the last decade

Ortega, Triana Lobatón; Rodríguez-Moranta, Francisco; Alonso, L. Rodriguez; Cancino, C. Parra; Dueñas, Eduardo Martínez de

doi:10.1016/s1873-9946(12)60436-x

Cited by 3 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Six studies (3.2% of all included studies) reported CDI incidence per 10,000 patient-days over time [23,[27][28][29][30][31]] -Fig. 3 presents studies reporting CDI cases identified in hospitals over time.…”

Section: Trends In Incidence Over Timementioning

confidence: 99%

See 1 more Smart Citation

Burden of Clostridioides difficile infection (CDI) - a systematic review of the epidemiology of primary and recurrent CDI

2021

View full text Add to dashboard Cite

Background Clostridioides difficile is a Gram-positive anaerobic bacterium, which causes Clostridioides difficile infection (CDI). It has been recognised as a leading cause of healthcare-associated infections and a considerable threat to public health globally. This systematic literature review (SLR) summarises the current evidence on the epidemiology and clinical burden of CDI. Methods A SLR was conducted to identify CDI and recurrent CDI (rCDI) epidemiology studies, to evaluate patient and disease characteristics, incidence rates, epidemiological findings and risk factors. Embase, MEDLINE and the Cochrane Library databases were searched for English articles from 2009 to 2019. Included territories were the United Kingdom, France, Germany, Italy, Spain, Poland, US, Canada, Australia, Japan and China. Results Of 11,243 studies identified, 165 fulfilled the selection criteria. An additional 20 studies were identified through targeted review of grey literature. The most widely reported findings were incidence and risk factors for CDI and rCDI. Among key studies reporting both healthcare-associated (HA-CDI) and community-associated CDI (CA-CDI) incidence rates for each country of interest, incidence rates per 10,000 patient days in the US were 8.00 and 2.00 for HA-CDI and CA-CDI, respectively. The highest incidence in Europe was reported in Poland (HA-CDI: 6.18 per 10,000 patient days, CA-CDI: 1.4 per 10,000 patient days), the lowest from the UK, at 1.99 per 10,000 patient days and 0.56 per 10,000 patient days for HA-CDI and CA-CDI, respectively. No clear trend for incidence over time emerged, with most countries reporting stable rates but some either a decrease or increase. Rates of recurrent CDI varied based on geographical setting. The rate of recurrence was lower in community-associated disease compared to healthcare-associated disease. Independent CDI risk factors identified common to both initial CDI and recurrent CDI included increasing age, antibiotic use, recent hospitalisation, and proton pump inhibitor (PPI) use. In addition, leukocyte count, length of hospital stays, and Charlson comorbidity index score featured as statistically significant risk factors for recurrent CDI, but these are not reported among the most common statistically significant risk factors for initial CDI. Conclusions Despite considerable heterogeneity, evidence suggests substantial incidence of recurrent and primary CDI, even after considerable efforts in the last decade.

show abstract

Section: Trends In Incidence Over Timementioning

confidence: 99%

“…Fig.3CDI incidence rate over time. Sources: Katz et al[23], Roncarati et al[30], Khanafer et al[29], Guardiola et al[27], Yoshikawa[31], and Kanamori[28] …”

mentioning

confidence: 99%