P4‐389: Alzheimer’S Care Via Telemedicine for Oregon (ACT‐ON), Phase II: a Pilot Study of to‐the‐Home Dementia Care Via Telemedicine

Abstract

MRS provided information on neural integrity (N-acetyl aspartate/ total creatine [NAA/tCr]), membrane turnover (total choline [tCho/ tCr]), and the glial marker myo-inositol (mI/tCr) from HC, ACC, and posterior cingulate cortex. Group differences were analysed using mixed models. Results: PME/PDE was higher after 4 weeks of test product compared to control (LS mean difference¼0.18, SEM¼0.06, p¼0.005). A similar effect was observed for PEth/ GPEth (LS mean difference¼0.22, SEM¼0.13, p¼0.091). Higher total choline after 4 weeks of test product compared to control was observed in the ACC and right hippocampus (LS mean differ-ence¼0.04 and 0.02; SEM¼0.02 and 0.01; p¼0.068 and 0.003, respectively). Significant group differences were found in nutritional blood markers, but not in other MRS measures. Conclusions: The current results suggest enhanced brain phospholipid formation compared to breakdown after 4 weeks intervention with Souvenaid in patients with mild AD. The observed effects indicate that Souvenaid not only raises circulating levels of nutrients and fatty acids, but also affects brain phospholipid metabolism in patients with mild AD, which confirms results from prior animal studies. This supports the hypothesis that Souvenaid enhances the formation of neuronal membranes.