P4‐315: TAU PET IMAGING WITH ¹⁸F‐PI2620 IN AGING AND ALZHEIMER'S DISEASE

Abstract

Blood labeling duration (LD) and postlabeling delay (PLD) design in the experiments T1 t2 t3 t4 t5 t6 t7 t8 t9 t10 t11 t12 LD (s) 1.

Evaluation of Imaging Windows for Tau PET Imaging Using 18F-PI2620 in Cognitively Normal Individuals, Mild Cognitive Impairment, and Alzheimer’s Disease Patients

“…Additionally, the all brain regions revealed average SUVR values over 1.25, especially in significant brain areas of the inferior temporal lobes, precuneus, posterior cingulate gyrus, and occipital lobe, associated with tau deposition in AD. [10][11][12][13][14] Our findings also corroborated those of Stephens et al, 15 Villemagne et al, 16 Mormino et al 17 and Muller et al, 18 who described similar results on the ability of this novel tau radiotracer to bind to tau protein in AD brain. While, the average SUVR of the cognitively normal individuals and MCI groups was similar average SUVR over time frames, but higher SUVR in all time frames at most regions of the AD group.…”

“…18 Conversely, the methodology in our study was adapted for application in actual practice. Firstly, the reduction of the acquisition protocol from previous studies which acquired the data 180 minutes (from 0 to 180 minutes post injection) 15,17 to about 45 minutes (30-75 minutes post injection) as suitable time for AD patients or incorporated subjects. Secondly, the SUVR calculated from cerebellum normalization uptake was selected for appropriate uptake time analysis, instead of SUV or TACs since we used the SUVR in routine clinical practice for AD diagnosis and PET interpretation based on SUVR average over time frame.…”

“…According to the plateaus of their SUVR time curves, Barret et al 20 selected an optimal time of 90-100 minutes post injection for the AD group and 60-70 minutes for the healthy control group. Mormino et al 17 used the uptake at 60-90 minutes for SUVR analysis. In accordance with Villemagne et al, 16 it showed tracer-reversible kinetics and an apparent steady state at 80-90 minutes after PI2620 injection.…”