P4‐293: Comparison of Three Normative Data Correction Approaches: A Cross‐sectional Evaluation in the Aibl Study

Burnham, Samantha; Raghavan, Nandini; Wilson, Brian; Baker, David S.; Ropacki, Michael T.; Novak, Gerald; Ames, David; Ellis, Kathryn A.; Martins, Ralph N.; Maruff, Paul; Masters, Colin L.; Romano, Gary; Rowe, Christopher C.; Savage, Greg; Twyman, Roy E.; Macaulay, Lance; Narayan, Vaibhav A.

doi:10.1016/j.jalz.2014.07.064

Cited by 3 publications

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“…In this study, a verbal episodic memory composite (CDR sum of boxes (CDR SB ), LMII, CVLT false positives (CVLT FP ) and long delay free recall (CVLT LDFR )), and a statistically driven global composite (CDR SB , MMSE, LMII, CVLT FP and Clock), aimed as a sensitive measure for longitudinal decline in individuals predisposed to AD 46 , were investigated across five study time points: baseline, 18, 36, 54 and 72 months. A correction for age, gender, years of education, WTAR-estimated premorbid IQ (WAIS-III Full Scale Intelligence Quotient (FSIQ)) and depressive symptoms (Geriatric Depression Scale (GDS)) was incorporated in the calculation of the cognitive composites 47 .…”

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confidence: 99%

KIBRA is associated with accelerated cognitive decline and hippocampal atrophy in APOE ε4-positive cognitively normal adults with high Aβ-amyloid burden

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Burnham

Doré

et al. 2018

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A single nucleotide polymorphism, rs17070145, in the KIdney and BRAin expressed protein (KIBRA) gene has been associated with cognition and hippocampal volume in cognitively normal (CN) individuals. However, the impact of rs17070145 on longitudinal cognitive decline and hippocampal atrophy in CN adults at greatest risk of developing Alzheimer’s disease is unknown. We investigated the impact rs17070145 has on the rate of cognitive decline and hippocampal atrophy over six years in 602 CN adults, with known brain Aβ-amyloid levels and whether there is an interactive effect with APOE genotype. We reveal that whilst limited independent effects of KIBRA genotype were observed, there was an interaction with APOE in CN adults who presented with high Aβ-amyloid levels across study duration. In comparison to APOE ε4-ve individuals carrying the rs17070145-T allele, significantly faster rates of cognitive decline (global, p = 0.006; verbal episodic memory, p = 0.004), and hippocampal atrophy (p = 0.04) were observed in individuals who were APOE ε4 + ve and did not carry the rs17070145-T allele. The observation of APOE effects in only non-carriers of the rs17070145-T allele, in the presence of high Aβ-amyloid suggest that carriers of the rs17070145-T allele are conferred a level of resilience to the detrimental effects of high Aβ-amyloid and APOE ε4.

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Section: Methodsmentioning

confidence: 99%

KIBRA is associated with accelerated cognitive decline and hippocampal atrophy in APOE ε4-positive cognitively normal adults with high Aβ-amyloid burden

Porter

Burnham

Doré

et al. 2018

Sci Rep

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“…In addition, the Pre-Alzheimer's cognitive composite (PACC) previously calculated by Donohue et al was also investigated [33]. In the calculation of the statistically driven composites there were corrections for age, sex, years of education, premorbid IQ (WTAR-estimated WAIS-III Full Scale Intelligence Quotient (FSIQ)) and depressive symptoms (Geriatric Depression Scale (GDS)) [34]. Five cognitive assessment time points were used: baseline, 18, 36, 54 and 72 months.…”

Section: Study Participantsmentioning

confidence: 99%

Cognitive gene risk profile for the prediction of cognitive decline in presymptomatic Alzheimer’s disease

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Villemagne

Savage

et al. 2018

Personalized Medicine in Psychiatry

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Utility of an Alzheimer’s Disease Risk-Weighted Polygenic Risk Score for Predicting Rates of Cognitive Decline in Preclinical Alzheimer’s Disease: A Prospective Longitudinal Study

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Burnham

Milicic

et al. 2018

JAD

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P4‐293: Comparison of Three Normative Data Correction Approaches: A Cross‐sectional Evaluation in the Aibl Study

Cited by 3 publications

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KIBRA is associated with accelerated cognitive decline and hippocampal atrophy in APOE ε4-positive cognitively normal adults with high Aβ-amyloid burden

KIBRA is associated with accelerated cognitive decline and hippocampal atrophy in APOE ε4-positive cognitively normal adults with high Aβ-amyloid burden

Cognitive gene risk profile for the prediction of cognitive decline in presymptomatic Alzheimer’s disease

Utility of an Alzheimer’s Disease Risk-Weighted Polygenic Risk Score for Predicting Rates of Cognitive Decline in Preclinical Alzheimer’s Disease: A Prospective Longitudinal Study

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