P4‐284: Vascular risk factors confer domain‐specific deficits in cognitive performance within an elderly russian population

Makeeva, O. A.; Romero, Heather; Markova, Valentina V.; Melikyan, Zarui A.; Жукова, И. А.; Minaycheva, L. I.; Буйкин, С. В.; Жукова, Н. Г.; Maruyama, Yuka; Plassman, Brenda L.; Roses, Allen D.; Welsh‐Bohmer, Kathleen A.

doi:10.1016/j.jalz.2015.08.114

Cited by 4 publications

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“…A sample of 708 elderly subjects (age range between 59–89 years, the mean age 70.8 years) of Russian descent was randomly selected from a population-based cohort study on primary prevention of the Alzheimer's disease in Tomsk, Russia [ 20 , 21 ]. Cognitive performance was assessed using the Montreal Cognitive Assessment (MoCA) as previously described in [ 20 ].…”

Section: Methodsmentioning

confidence: 99%

Analysis of Association of Genetic Markers in the LUZP2 and FBXO40 Genes with the Normal Variability in Cognitive Performance in the Elderly

Степанов

Вагайцева

Бочарова

et al. 2018

International Journal of Alzheimer's Disease

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Cognitive performance is an important endophenotype for various neurodegenerative and neuropsychiatric traits. In the present study two genetic variants in the leucine-zipper protein (LUZP2) and the F-box 40 protein (FBXO40) genes, previously reported to be genome-wide significant for Alzheimer's diseases and schizophrenia, were examined for an association with cognitive abilities in normal elderly from the Russian population. Rs1021261 in the LUZP2 and rs3772130 in the FBXO40 were genotyped by multiplex PCR and MALDI-TOF mass spectrometry in a sample of 708 normal elderly subjects tested for cognitive performance using the Montreal Cognitive Assessment (MoCA). Association of genetic variability with the MoCA scores was estimated by parametric and nonparametric analysis of variance and by the frequency comparison between upper and lower quartiles of MoCA distribution. Significantly higher frequency of “TT” genotype of rs1021261 in the LUZP2 gene as well as “A” allele and “AA” genotype of rs3772130 in the FBXO40 gene was found in a subsample of individuals with the MoCA score less than 20 comparing to the fourth quartile's subsample (MoCA > 25). The data of the present study suggests that genetic variability in the LUZP2 and FBXO40 loci associated with neurodegenerative and neuropsychiatric diseases is also contributed to the normal variability in cognitive performance in the elderly.

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Section: Methodsmentioning

confidence: 99%

Analysis of Association of Genetic Markers in the LUZP2 and FBXO40 Genes with the Normal Variability in Cognitive Performance in the Elderly

Степанов

Вагайцева

Бочарова

et al. 2018

International Journal of Alzheimer's Disease

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“…The study protocol was approved by the Ethics Committee of the Research Institute of Medical Genetics, Tomsk, Russian Federation. Sample of 700 elderly individuals without dementia and neurological diseases (age range 59–89 years, mean age 70.8 years) of Russian descent was randomly selected from a population-based cohort study on primary prevention of Alzheimer's disease in Tomsk, Russia [6] , [7] . All of the studied individuals were Caucasians from the same ethnic (Russian) and geographical origin, living in the Tomsk region of Russian Federation.…”

Section: Experimental Design Materials and Methodsmentioning

confidence: 99%

Frequencies of alleles, genotypes and haplotypes of two polymorphisms in the clusterin gene in the Russian elderly population categorized by cognitive performance

et al. 2018

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This article contains data on the frequencies of alleles, genotypes and haplotypes of the single nucleotide polymorphisms (SNPs) rs2279590 and rs1532278 in the CLU gene in a cohort of normal elderly from the Russian population. The SNPs have been reported to be associated with Alzheimer's disease and cognitive functions in genome-wide and candidate genes association studies. Cognitive performance in sample set was estimated by the Montreal Cognitive Assessment (MoCA). The frequencies of alleles, genotypes and haplotypes of two SNPs were calculated in 3 groups: total sample set, sample set with MoCA score less than 21 (the first quartile) and group with MoCA score more than 24 (the fourth quartile).

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“…708 elderly individuals of European Russian descent without dementia and neurological diseases were recruited from a population-based cohort study on primary prevention of Alzheimer's disease in Tomsk, Russia [ 12 , 13 ]. The sample consisted of 74% of females (see Table 1 ).…”

Section: Methodsmentioning

confidence: 99%

Genetic Variants in CSMD1 Gene Are Associated with Cognitive Performance in Normal Elderly Population

Степанов

Marusin

Вагайцева

et al. 2017

Genetics Research International

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Recently, genetic markers rs10503253 and rs2616984 in the CUB and Sushi multiple domains-1 (CSMD1) gene have been reported to be associated with schizophrenia and cognitive functions in genome-wide association studies. We examined the associations of the above SNPs with cognitive performance evaluated by the Montreal Cognitive Assessment (MoCA) tool in a cohort of the normal elderly from the Russian population. Significant association of rs2616984 genotypes with the MoCA scores was found using nonparametric analysis. No association of rs10503253 with MoCA scores was observed using both parametric and nonparametric statistics. Significant combined effect of two-locus CSMD1 genotypes on MoCA scores was demonstrated by median test. Allele “A” and genotype “AA” of rs2616984 were significantly associated with the lower MoCA scores in comparison of 1st and 4th quartiles of MoCA total score distribution. The results suggest that genetic variants in CSMD1 gene are likely a part of genetic component of cognitive performance in the elderly.

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P4‐284: Vascular risk factors confer domain‐specific deficits in cognitive performance within an elderly russian population

Cited by 4 publications

References 0 publications

Analysis of Association of Genetic Markers in the LUZP2 and FBXO40 Genes with the Normal Variability in Cognitive Performance in the Elderly

Analysis of Association of Genetic Markers in the LUZP2 and FBXO40 Genes with the Normal Variability in Cognitive Performance in the Elderly

Frequencies of alleles, genotypes and haplotypes of two polymorphisms in the clusterin gene in the Russian elderly population categorized by cognitive performance

Genetic Variants in CSMD1 Gene Are Associated with Cognitive Performance in Normal Elderly Population

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