P4.14 Prevalence of Diastolic Left Ventricular Dysfunction in European Populations Based on Cross-Validated Diagnostic Thresholds

Kloch−Badełek, Małgorzata; Kuznetsova, Tatiana; Sakiewicz, W.; Tikhonoff, Valérie; Ryabikov, A.; Loster, Magdalena; Stolarz‐Skrzypek, Katarzyna; Thijs, Lutgarde; Staessen, Jan A; Kawecka‐Jaszcz, K.; Czarnecka, Danuta

doi:10.1016/j.artres.2015.10.258

Cited by 5 publications

(15 citation statements)

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“…The heritability reflects how much of the variation in left ventricular diastolic function traits is due to variation in genetic factors. In our population-based study [2], the age-standardized prevalence of diastolic left ventricular dysfunction range from 22.4 till 25.1%. We additionally calculated the regression coefficients between offspring and midparent [13].…”

Section: Discussionmentioning

confidence: 76%

“…In the present study, one experienced observer in each centre recorded all Doppler images using a common standardized imaging protocol [2]. First, the Doppler transmitral blood flow measurements and the TDI velocities are prone to measurements error.…”

Section: Heritability Of Left Ventricular Diastolic Functionmentioning

confidence: 99%

“…Recently published population studies revealed a high prevalence (up to 34.7%) of left ventricular diastolic dysfunction using comprehensive conventional and tissue Doppler (TDI) echocardiographic imaging [1][2][3][4]. Left ventricular diastolic dysfunction refers to a condition in which abnormalities in left ventricular function are present during diastole.…”

Section: Introductionmentioning

confidence: 99%

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Heritability and other determinants of left ventricular diastolic function in the family-based population study

Kloch−Badełek

Knez

Tikhonoff

et al. 2014

Journal of Hypertension

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Section: Discussionmentioning

confidence: 76%

Section: Heritability Of Left Ventricular Diastolic Functionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Heritability and other determinants of left ventricular diastolic function in the family-based population study

Kloch−Badełek

Knez

Tikhonoff

et al. 2014

Journal of Hypertension

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“…As described elsewhere, guideline‐driven echocardiographic criteria to stage patients with advanced diastolic LV dysfunction leave a large proportion of people unclassified in population studies. We therefore developed age‐specific criteria in a healthy reference sample drawn from FLEMENGHO and replicated these criteria in an independent European population study . Diastolic LV dysfunction included: (1) patients with an abnormally low age‐specific transmitral E/A ratio indicative of impaired relaxation, but without evidence of increased LV filling pressures (E/e′ ≤8.5); (2) patients with a mildly‐to‐moderately elevated LV filling pressure (E/e′ >8.5) and an E/A ratio within the normal age‐specific range; and (3) patients with an elevated E/e′ ratio and an abnormally low age‐specific E/A ratio (combined dysfunction).…”

Section: Methodsmentioning

confidence: 99%

“…The lower limit of detection was 5 pg of NT‐proBNP per mL. In the FLEMENGHO study, NT‐proBNP was measured in plasma by a competitive enzyme immunoassay for research use (Biomedica Gruppe, Vienna, Austria) . The interassay and intra‐assay variations were lower than 15%.…”

Section: Methodsmentioning

confidence: 99%

Novel Urinary Peptidomic Classifier Predicts Incident Heart Failure

Zhang

Ravassa

Nkuipou‐Kenfack

et al. 2017

JAHA

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BackgroundDetection of preclinical cardiac dysfunction and prognosis of left ventricular heart failure (HF) would allow targeted intervention, and appears to be the most promising approach in its management. Novel biomarker panels may support this approach and provide new insights into the pathophysiology.Methods and ResultsA retrospective comparison of urinary proteomic profiles generated by mass spectrometric analysis from 49 HF patients, 36 patients who progressed to HF within 2.6±1.6 years, and 192 sex‐ and age‐matched controls who did not progress to HF enabled identification of 96 potentially HF‐specific peptide biomarkers. Based on these 96 peptides, the classifier called Heart Failure Predictor (HFP) was established by support vector machine modeling. The incremental prognostic value of HFP was subsequently evaluated in urine samples from 175 individuals with asymptomatic diastolic dysfunction from an independent population cohort. Within 4.8 years, 17 of these individuals progressed to overt HF. The area under receiver‐operating characteristic curve was 0.70 (95% CI, 0.56–0.82); P=0.0047 for HFP and 0.57 (0.42–0.72; P=0.62) for N‐terminal pro b‐type natriuretic peptide. Hazard ratios were 1.63 (CI, 1.04–2.55; P=0.032) per 1‐SD increment in HFP and 0.70 (CI, 0.35–1.41; P=0.32) for a doubling of the logarithmically transformed N‐terminal pro b‐type natriuretic peptide.Conclusions HFP is a novel biomarker derived from the urinary proteome and might serve as a sensitive tool to improve risk stratification, patient management, and understanding of the pathophysiology of HF.

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Prognostic Value of Left Ventricular Diastolic Dysfunction in a General Population

Kuznetsova

Thijs

Knez

et al. 2014

JAHA

106

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BackgroundNew techniques of Tissue Doppler Imaging (TDI) enable the measurement of myocardial velocities and provide information about left ventricular (LV) diastolic function. Recent studies explored the prognostic role of TDI‐derived indexes. However, these studies considered only total mortality and did not provide information on cardiovascular mortality and morbidity. Therefore, we investigated in continuous and categorical analyses whether Doppler diastolic indexes contained any prognostic information over and beyond traditional cardiovascular risk factors in a general population.Methods and ResultsWe measured early and late diastolic peak velocities of mitral inflow (E and A) by conventional Doppler, and the mitral annular velocities (e' and a') by TDI in 793 participants (mean age 50.9 years). We calculated multivariable‐adjusted hazard ratios for conventional and TDI Doppler indexes, while accounting for family cluster and cardiovascular risk factors. Median follow‐up was 4.8 years (5th to 95th percentile, 3.0 to 5.4). With adjustments applied for covariables, e' velocity was a significant predictor of fatal and nonfatal cardiovascular (n=59; P=0.004) and cardiac events (n=40; P=0.001). TDI e' yielded a net reclassification improvement of 54.2% for cardiovascular and 64.0% for cardiac events. Hazard ratios of all cardiovascular (2.21; P=0.042) and cardiac (4.50; P=0.002) events were significantly elevated in participants with increased LV filling pressure compared with subjects with normal diastolic function.ConclusionsTDI e' velocity is a significant predictor of fatal and nonfatal cardiovascular events in a general population. Furthermore, we observed an increase in all cardiovascular events in the diastolic dysfunction group characterized by elevated LV filling pressure.

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P4.14 Prevalence of Diastolic Left Ventricular Dysfunction in European Populations Based on Cross-Validated Diagnostic Thresholds

Cited by 5 publications

References 0 publications

Heritability and other determinants of left ventricular diastolic function in the family-based population study

Heritability and other determinants of left ventricular diastolic function in the family-based population study

Novel Urinary Peptidomic Classifier Predicts Incident Heart Failure

Prognostic Value of Left Ventricular Diastolic Dysfunction in a General Population

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