P4‐041: Voluntary exercise ameliorates both cognitive and noncognitive symptoms in the 3xTgAD mouse

García, Yoelvis; Revilla, Susana; Cristòfol, Rosa; Suñol, Crsistina; LaFerla, Frank M.; Giménez‐Llort, Lydia; Sanfeliu, Coral

doi:10.1016/j.jalz.2009.04.911

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“…As few as 2–5 weeks of moderate intensity, treadmill running has been demonstrated to promote nerve cell regeneration and improve learning and memory in rodents [ 25 – 27 ]. However, some previous studies of treadmill effects in AD transgenic mice were extended to 12 weeks [ 17 , 19 ] or 16 weeks [ 18 , 28 ]. This study evaluates the effects of just 5 weeks of treadmill exercise on the brain and peripheral organ function of 3xTg-AD mice at several levels of study, namely the cellular (oxidative stress), neurochemical (GABA function), physiological (body weight curve, glucose homeostasis), immunoendocrine (involution of thymus, plasma levels of glucocorticoids), behavioral (BPSD-like and cognition impairments), and neuropathological (presence of amyloid and tau pathologies).…”

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confidence: 99%

Gender-Specific Neuroimmunoendocrine Response to Treadmill Exercise in 3xTg-AD Mice

Giménez-Llort

García

Buccieri

et al. 2010

International Journal of Alzheimer's Disease

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The 3xTg-AD mouse develops a progressive Alzheimer's disease- (AD-) like brain pathology that causes cognitive- and neuropsychiatric-like symptoms of dementia. Since its neuroimmunoendocrine axis is likewise impaired, this mouse is also useful for modelling complex age-related neurodegeneration. This study analyzed behavioral, physiological, neurochemical, pathological and immunoendocrine alterations in male and female 3xTg-AD mice and assayed the effects of a short therapy of forced physical exercise at the moderate pathology stage of 6 months of age. Gender effects were observed in most AD-related pathology and dysfunctions. Five weeks of treadmill training produced beneficial effects, such as the reduction of brain oxidative stress and GABA-A receptor dysfunction in males and improvement of sensorimotor function in females. In both sexes, exercise decreased the brain amyloid β 42/40 ratio levels. The results highlight the importance of analyzing experimental therapies in both mouse model genders in order to improve our understanding of the disease and develop more appropriate therapies.

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