2005
DOI: 10.1016/j.burns.2004.10.015
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p38 mitogen-activated protein kinase inhibition attenuates burn-induced liver injury in rats

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Cited by 28 publications
(15 citation statements)
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“…Furthermore, glucose release is not increased in isolated perfused livers from burned animals, indicating that the increased glucose output is secondary to extrahepatic signaling such as via catecholamines (18,62). Catecholamines also stimulate p38 mitogen-activated protein kinase, causing the release of tumor necrosis factor-␣ (TNF-␣) and interleukin-1 (IL-1), which activate nuclear factor-B (NF-B) via IKK (19). NF-B is also activated by saturated plasma FFA, elevated secondary to the catecholamines, via toll-like receptor-4 (57, 61).…”
Section: Tissue-specific Interactions Between Glucose and Fat Metabolismmentioning
confidence: 99%
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“…Furthermore, glucose release is not increased in isolated perfused livers from burned animals, indicating that the increased glucose output is secondary to extrahepatic signaling such as via catecholamines (18,62). Catecholamines also stimulate p38 mitogen-activated protein kinase, causing the release of tumor necrosis factor-␣ (TNF-␣) and interleukin-1 (IL-1), which activate nuclear factor-B (NF-B) via IKK (19). NF-B is also activated by saturated plasma FFA, elevated secondary to the catecholamines, via toll-like receptor-4 (57, 61).…”
Section: Tissue-specific Interactions Between Glucose and Fat Metabolismmentioning
confidence: 99%
“…NF-B is also activated by saturated plasma FFA, elevated secondary to the catecholamines, via toll-like receptor-4 (57, 61). Once activated, NF-B can cause apoptosis, and hepatocyte damage has been documented following burn trauma and serious illness (19,53,105). NF-B also induces the production of IL-6, and this can cause increased hepatic glucose release and hepatic insulin resistance (54,102).…”
Section: Tissue-specific Interactions Between Glucose and Fat Metabolismmentioning
confidence: 99%
“…The nuclear protein extracts from frozen mucosal tissues were prepared as described previously (35). The protein concentration was measured by the BCA assay.…”
Section: Preparation Of Nuclear Extracts and Emsamentioning
confidence: 99%
“…Furthermore, our findings may also be relevant to other forms of systemic inflammatory activation such as burns [49], ischemia-reperfusion [50] and cardiopulmonary bypass [51,52], where p38MAPK activation and its relation to multi-organ dysfunction is becoming increasingly clear. Inhibitors of the p38MAPK pathway are being investigated in animal and human studies of sepsis and other pro-15 inflammatory disease states [52][53][54][55][56]. Modulation of up-or downstream regulators of this pathway could also be of interest therapeutically.…”
mentioning
confidence: 99%