p38 MAP kinase is involved in the signalling of sphingosine in osteoblasts

Kozawa, Osamu; Kawamura, Hidenori; Matsuno, Hiroyuki

doi:10.1016/s0898-6568(00)00086-3

Cited by 6 publications

(2 citation statements)

References 17 publications

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“…Two publications pointed out that PKC could function upstream of the p38 MAPK pathway in osteoblat and epithelial cell lines [37,42]. Other investigators have demonstrated that PI-3K/NF-B and PGE2/cAMP pathways were respectively involved in the production of MMP-9 by LPS-activated human monocytes [43] and the myeloid MonoMac6 cell line stimulated by TNF-␣ [44].…”

Section: Discussionmentioning

confidence: 99%

Protein tyrosine kinase and p38 MAP kinase pathways are involved in stimulation of matrix metalloproteinase-9 by TNF-α in human monocytes

et al. 2006

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Section: Discussionmentioning

confidence: 99%

Protein tyrosine kinase and p38 MAP kinase pathways are involved in stimulation of matrix metalloproteinase-9 by TNF-α in human monocytes

et al. 2006

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“…Contrary to sphingosine 1-phosphate (S1P), sphingosine inhibits PGF 2 α-induced phosphoinositide hydrolysis by PLC via p38 MAP kinase in osteoblasts. [435,436]. …”

Section: Pi-specific Phospholipase Cmentioning

confidence: 99%

Phospholipases of Mineralization Competent Cells and Matrix Vesicles: Roles in Physiological and Pathological Mineralizations

Mébarek

Abousalham

Magne

et al. 2013

IJMS

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The present review aims to systematically and critically analyze the current knowledge on phospholipases and their role in physiological and pathological mineralization undertaken by mineralization competent cells. Cellular lipid metabolism plays an important role in biological mineralization. The physiological mechanisms of mineralization are likely to take place in tissues other than in bones and teeth under specific pathological conditions. For instance, vascular calcification in arteries of patients with renal failure, diabetes mellitus or atherosclerosis recapitulates the mechanisms of bone formation. Osteoporosis—a bone resorbing disease—and rheumatoid arthritis originating from the inflammation in the synovium are also affected by cellular lipid metabolism. The focus is on the lipid metabolism due to the effects of dietary lipids on bone health. These and other phenomena indicate that phospholipases may participate in bone remodelling as evidenced by their expression in smooth muscle cells, in bone forming osteoblasts, chondrocytes and in bone resorbing osteoclasts. Among various enzymes involved, phospholipases A1 or A2, phospholipase C, phospholipase D, autotaxin and sphingomyelinase are engaged in membrane lipid remodelling during early stages of mineralization and cell maturation in mineralization-competent cells. Numerous experimental evidences suggested that phospholipases exert their action at various stages of mineralization by affecting intracellular signaling and cell differentiation. The lipid metabolites—such as arachidonic acid, lysophospholipids, and sphingosine-1-phosphate are involved in cell signaling and inflammation reactions. Phospholipases are also important members of the cellular machinery engaged in matrix vesicle (MV) biogenesis and exocytosis. They may favour mineral formation inside MVs, may catalyse MV membrane breakdown necessary for the release of mineral deposits into extracellular matrix (ECM), or participate in hydrolysis of ECM. The biological functions of phospholipases are discussed from the perspective of animal and cellular knockout models, as well as disease implications, development of potent inhibitors and therapeutic interventions.

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Cellular Signaling by Sphingosine and Sphingosine 1-Phosphate

Pyne

Subcellular Biochemistry

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p38 MAP kinase is involved in the signalling of sphingosine in osteoblasts

Cited by 6 publications

References 17 publications

Protein tyrosine kinase and p38 MAP kinase pathways are involved in stimulation of matrix metalloproteinase-9 by TNF-α in human monocytes

Protein tyrosine kinase and p38 MAP kinase pathways are involved in stimulation of matrix metalloproteinase-9 by TNF-α in human monocytes

Phospholipases of Mineralization Competent Cells and Matrix Vesicles: Roles in Physiological and Pathological Mineralizations

Cellular Signaling by Sphingosine and Sphingosine 1-Phosphate

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