P367 Safety and immunogenicity of new chromatographically purified Vero cell rabies vaccine (CPRV) for human use in pre- and post-exposure rabies

Fractional dose of intradermal compared to intramuscular and subcutaneous vaccination - A systematic review and meta-analysis

“…Thirty-two studies compared ID immunisation to SC immunisation, and two studies compared ID immunisation to both. The majority of studies was conducted on influenza (n = 5 1) [39–89], HBV (n = 43) [ 17 , [90] , [131] ] and rabies (n = 37) [ 14 , 15 , [132] , [133] , [134] , [135] , [136] , [137] , [138] , [139] , [140] , [141] , [142] , [143] , [144] , [145] , [146] , [147] , [148] , [149] , [150] , [151] , [152] , [153] , [154] , [155] , [156] , [157] , [158] , [159] , [160] , [161] , [162] , [163] , [164] , [165] , [166] ] vaccines. The remaining studies were conducted on IPV [ [167] , [168] , [169] , [170] , [171] , [172] , [173] ], measles [ 10 , [174] , [175] , [176] , [177] , [178] ], hepatitis A (HAV) [ [179] , [180] , [181] , [182] ], diphtheria-tetanus-pertussis (DTP) [ 183 , 184 ], Japanese encephalitis (JE) [ 185 ,…”

“…A total of 37 studies were conducted on rabies vaccines [ 14 , 15 , [132] , [133] , [134] , [135] , [136] , [137] , [138] , [139] , [140] , [141] , [142] , [143] , [144] , [145] , [146] , [147] , [148] , [149] , [150] , [151] , [152] , [153] , [154] , [155] , [156] , [157] , [158] , [159] , [160] , [161] , [162] , [163] , [164] , [165] , [166] ]. Since we only considered licensed and available vaccines in this review, only human diploid cell vaccines (HDCV), purified Vero cell rabies vaccines (PVRV) and purified chick embryo cell vaccines (PCECV) were included.…”

“…Participants of pre-exposure prophylaxis (PrEP) studies were immune naïve predominantly healthy adults. Twenty-two PrEP studies compared ID to IM immunisation [ 14 , 136 , [138] , [139] , [140] , [143] , [144] , [145] , [146] , [147] , [149] , [150] , [151] , [153] , [154] , [155] , 157 , 158 , [161] , [162] , [163] , 166 ]; two studies [ 132 , 141 ] compared ID to SC immunisation, and one study [ 15 ] compared ID with both IM and SC immunisation. ID doses consisted of either one injection of 0.1 ml or, in eight studies [ [143] , [144] , [145] , [146] , 160 , [164] , [165] , [166] ], of multiple injections of 0.1 ml.…”

“…IM doses consisted of 0.5 or 1 ml, and SC doses of 0.25, 1 or 2 ml, respectively. Sixteen studies used the WHO-recommend regimen for both ID and IM immunisation, administering vaccines on day 0, 7 and 21 or 28 [ 15 , 136 , [138] , [139] , [140] , 143 , 147 , 150 , 151 , 153 , 155 , 157 , 158 , 161 , 163 , 166 ].…”

“…Most studies investigating immunogenicity reported seroconversion rates (n = 21) ( Table 1 ) [ 133 , 134 , 136 , 139 , 140 , [143] , [144] , [145] , [146] , [147] , 149 , 150 , 155 , 156 , 158 , [160] , [161] , [162] , [163] , [164] , 166 ]. Mostly in vitro virus-neutralisation assays, as advised by the WHO [ 192 ], were used to assess Rabies virus neutralising antibodies (RVNAs).…”