P3515Identification of serum apurinic/apyrimidinic endonuclease 1/redox effector factor-1 (APE1/Ref-1) in mouse model of viral myocarditis; implication of a novel biomarker for myocarditis

Jin, Seong Eun; Lim, Byung-Kwan; Kim, S.K.; Seo, Hee Jung; Seo, B.S.; Kwon, Hee Jin; Seong, Seok-Woo; Jeong, Jin‐Ok; Seong, In‐Whan

doi:10.1093/eurheartj/ehx504.p3515

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There are many clinical manifestations of acute VMC, such as arrhythmia, atrial fibrillation and atrioventricular block, and severe sudden death can occur; the prognosis of most acute myocarditis is better, but there is a small section that of disease that undergoes transition to chronic VMC. With progress of the disease, acute and chronic VMC will have different degrees of myocardial fibrosis at all stages, and myocardial fibrosis is the main pathological basis for the development of multiple complications of VMC and myocarditis to cardiomyopathy (4).…”

Section: Introductionmentioning

confidence: 99%

Expression of ADAMTS‑1 mRNA in myocardium of viral heart disease mice and its clinical significance

Zhou

Song

et al. 2018

Exp Ther Med

View full text Add to dashboard Cite

The expression of ADAMTS-1 mRNA in myocardium of viral heart disease (VHD) mice was investigated to explore its role in myocardial fibrosis. A total of 150 purebred inbred Balb/c mice were used in this study. According to the principle of similar body weight, 50 mice were selected to make an acute viral myocarditis (VMC) animal model (acute VMC group), and 50 mice were selected to make a chronic VMC animal model (chronic VMC group), and the remaining 50 mice were selected as a control group. RT-qPCR was used to detect the relative expression of transforming growth factor-β1 (TGF-β1) mRNA and ADAMTS-1 mRNA in myocardial tissue of three groups of mice, and their relationship in myocardial fibrosis was analyzed. Compared with the control group, the collagen volume fraction (CVF) in the myocardial tissue of the acute VMC group was significantly increased, and the increase of CVF in the myocardial tissue of the chronic VMC group was the most significant (p<0.001). Compared with the control group, the relative expression of TGF-β1 mRNA and ADAMTS-1 mRNA in myocardial tissue of the mice in the acute and chronic VMC group were significantly increased (p<0.001). The relative expression of TGF-β1 mRNA and ADAMTS-1 mRNA in myocardial tissue of chronic VMC group was significantly higher than that of acute VMC group (p<0.001). Pearson's correlation test results showed that ADAMTS-1 mRNA was positively correlated with CVF and TGF-β1 mRNA, and the correlation coefficients were (r=0.351, p<0.01, r=0.401, p<0.01). ADAMTS-1 is involved in the occurrence and development of myocardial fibrosis, and it is positively correlated with CVF and TGF-β1. It may play a role in promoting myocardial fibrosis during the development of VHD. It can be used as a biological index for predicting myocardial fibrosis.

show abstract

Section: Introductionmentioning

confidence: 99%