P3223 Surface 12-lead electrocardiogram waveform analysis in patients with atrial fibrillation: a tool for evaluating the effects of intervention?

Surface Atrial Frequency Analysis in Patients with Atrial Fibrillation: Assessing the Effects of Linear Left Atrial Ablation

“…These results establish that measurements of atrial frequency can be obtained from surface 12‐lead ECG recordings during AF and change as predicted in response to linear left atrial ablation. Combining the results of this with our earlier study, 10 we have now validated the robustness of this frequency measure in response to drug and ablation interventions. This technique may be useful in assessing antiarrhythmic treatments for AF.…”

“…In our initial study, we reported that atrial frequency parameters could be obtained in patients with AF from simultaneous 12‐lead Holter ECG recordings, using a combination of principal component and fast Fourier transform algorithms, and that these measurements were reproducible and changed as predicted in response to drug manipulation of the arrhythmia 10 . The results of this present study demonstrate that this form of analysis can also measure changes in atrial frequency brought about by specific left atrial linear ablation lesions, known to organize AF and facilitate its spontaneous termination.…”

“…Previous work from our group 10 has shown that atrial frequency parameters in patients with AF can be obtained from simultaneous 12‐lead Holter ECG recordings, using a combination of principal component and fast Fourier transform algorithms. Measurements of atrial frequency and variability, obtained using this technique, are reproducible and have been shown to change in response to drug manipulation of the arrhythmia.…”