P311 modulates hepatic stellate cells migration

Abstract

P311 is central to reactive oxygen species-mediated HSC migration induced by different chemokines.

Silibinin Inhibits Proliferation and Migration of Human Hepatic Stellate LX-2 Cells

“…41 Several in vitro and in vivo studies have shown concrete evidences of HSCs migration toward the areas of tissue remodeling. 3,4 In this study, LX-2 cells exposed to SBN at increasing concentrations for 24 h in serum supplemented medium show a decrease in the migration of the LX-2 toward the scrap wound induced in the culture. This delaying process of HSCs migration toward wound area and the anti-proliferative responses of proliferating cells by SBN treatments could be utilized beneficially toward delaying hepatic fibrosis.…”

“…In vitro and in vivo studies have shown that proliferation and migration of HSCs toward the areas of tissue remodeling may be an additional factor contributing to wound healing and fibrosis. 3,4 Hence, prevention of HSC proliferation together with its migration toward the microenvironment of injury in the liver regarded as one of the key strategies to reduce the progression of hepatic fibrosis.…”

P311, Friend, or Foe of Tissue Fibrosis?

“…Fibroblast migration is a key event for organ development as well as fibrosis ( Shimizu et al, 2001 ; Hattori et al, 2004 ; Scholten et al, 2011 ). P311 is described by different groups to play an important role during chemokine-induced cell migration ( Studler et al, 1993 ; Mariani et al, 2001 ; McDonough et al, 2005 ; Guimaraes et al, 2015 ). The first study ever describing P311 already detected the mRNA in migrating cells in the developing brain ( Studler et al, 1993 ).…”

“…This correlation between P311 and cell migration was also shown during liver fibrosis. Upon liver injury, hepatic stellate cells activate, resulting in contractile and migrating hepatic stellate cells with increased P311 transcription ( Guimaraes et al, 2015 ). When activated chronically, these cells deposit high levels of collagen, resulting in liver fibrosis and finally cirrhosis.…”

“…When activated chronically, these cells deposit high levels of collagen, resulting in liver fibrosis and finally cirrhosis. Knocking down P311 expression in cultured primary hepatic stellate cells reduced chemokine-dependent cell migration ( Guimaraes et al, 2015 ). Furthermore, immunohistochemical stainings demonstrated that the P311 protein was present in nuclei as well as at leading edges of migrating hepatic stellate cells and human astrocytes ( Taylor et al, 2000 ; Guimaraes et al, 2015 ).…”