P303 Impact of HAART in HIV patients with multicentric Castleman's disease

Perales, Isabel; Múñez, Elena; Espert, I.; Ramos, Alberto Ramírez; Martin, T.

doi:10.1016/s0953-6205(03)91566-4

Cited by 1 publication

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This unmasking of an occult disease after initiation of antiretroviral therapy is referred to as immune reconstitution inflammatory syndrome (IRIS). While it is recognised that Kaposi's sarcoma tends to improve with HAART, data regarding the effect of HAART on multicentric Castleman's disease is conflicting [2,3] . While some report successful treatment of the condition with HAART alone, others claim that multicentric Castleman's disease does not regress with HAART alone [2][3][4] .…”

Section: Case Presentationmentioning

confidence: 99%

“…While it is recognised that Kaposi's sarcoma tends to improve with HAART, data regarding the effect of HAART on multicentric Castleman's disease is conflicting [2,3] . While some report successful treatment of the condition with HAART alone, others claim that multicentric Castleman's disease does not regress with HAART alone [2][3][4] . Several treatment options have been described for multicentric Castleman's disease, however because of the variety of clinical contexts and the rarity of the disease, there is no standard treatment yet.…”

Section: Case Presentationmentioning

confidence: 99%

See 1 more Smart Citation

Lymphadenopathy after initiating HAART in an HIV-positive patient with Kaposi's sarcoma: A case of multicentric Castleman's disease

Micallef

Attard

Azzopardi

et al. 2015

European Journal of Case Reports in Internal Medicine

View full text Add to dashboard Cite

We present the case of a 33-year-old lady who was diagnosed with disseminated Kaposi’s sarcoma and HIV infection. The patient improved on highly active antiretroviral therapy (HAART), however, nine days into treatment, she became febrile and dyspnoeic and developed tender cervical and axillary lymphadenopathy. Despite treatment for suspected sepsis and immune reconstitution, she died in intensive care. Lymph node biopsies revealed coexistent Castleman’s disease and Kaposi’s sarcoma. Initiation of HAART can be rarely associated with unmasking and rapid progression of Castleman’s disease, a phenomenon called immune reconstitution. Urgent investigation and treatment with agents such as steroids and cytotoxic drugs can be life-saving.

show abstract