P300 waveform and dopamine transporter availability: a controlled EEG and SPECT study in medication-naive patients with schizophrenia and a meta-analysis

Chen, K. C.; Lee, I. H.; Yang, Yen Kuang; Landau, Sabine; Chang, Wen-Teng; Chen, P. S.; Lu, Ru Band; David, Anthony S.; Bramon, Elvira

doi:10.1017/s0033291713002808

Cited by 15 publications

(14 citation statements)

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“…Progression of illness may also play an important role. 11 The present study has several limitations. First, the sample size is relatively small; a greater number of participants is required to improve the power of the current results.…”

Section: Discussionmentioning

confidence: 83%

Availability of dopamine transporters and auditory P300 abnormalities in adults with attention-deficit hyperactivity disorder: preliminary results

et al. 2017

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Section: Discussionmentioning

confidence: 83%

Availability of dopamine transporters and auditory P300 abnormalities in adults with attention-deficit hyperactivity disorder: preliminary results

et al. 2017

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“…Previous studies showed that high frequency magnetic stimulation increases anterior brain glutamate levels, in some cases with a left lateralization [ 29 – 32 ]. It is also known that dopamine modulation can influence both task performance testing and also event related potentials [ 33 , 34 ]. ERP latencies and amplitudes can be influenced by dopaminergic function, impacting cognitive speed processing and also neural resources magnitude allocation to a specific task.…”

Section: Discussionmentioning

confidence: 99%

Bilateral theta-burst magnetic stimulation influence on event-related brain potentials

et al. 2018

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Theta-burst stimulation (TBS) can be a non-invasive technique to modulate cognitive functions, with promising therapeutic potential, but with some contradictory results. Event related potentials are used as a marker of brain deterioration and can be used to evaluate TBS-related cognitive performance, but its use remains scant. This study aimed to study bilateral inhibitory and excitatory TBS effects upon neurocognitive performance of young healthy volunteers, using the auditory P300’ results. Using a double-blind sham-controlled study, 51 healthy volunteers were randomly assigned to five different groups, two submitted to either excitatory (iTBS) or inhibitory (cTBS) stimulation over the left dorsolateral pre-frontal cortex (DLPFC), two other actively stimulated the right DLPFC and finally a sham stimulation group. An oddball based auditory P300 was performed just before a single session of iTBS, cTBS or sham stimulation and repeated immediately after. P300 mean latency comparison between the pre- and post-TBS stimulation stages revealed significantly faster post stimulation latencies only when iTBS was performed on the left hemisphere (p = 0.003). Right and left hemisphere cTBS significantly delayed P300 latency (right p = 0.026; left p = 0.000). Multiple comparisons for N200 showed slower latencies after iTBS over the right hemisphere. No significant difference was found in amplitude variation. TBS appears to effectively influence neural networking involved in P300 formation, but effects seem distinct for iTBS vs cTBS and for the right or the left hemisphere. P300 evoked potentials can be an effective and practical tool to evaluate transcranial magnetic stimulation related outcomes.

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“…To answer this question, we took the results from a recent schizophrenia genetic association meta-analysis by the Psychiatric Genomics Consortium (PGC), which discovered 128 independent genetic variants in 108 genomic loci associated with schizophrenia (Schizophrenia Working Group of the Psychiatric Genomics Consortium, 2014), and tested them for association with the same 17 endophenotypes described above. Many of these endophenotypes have demonstrated substantial construct validity as endophenotypes for schizophrenia (Iacono et al 2016); others less so, but nevertheless have been associated with schizophrenia, found to be heritable in twin studies, and show deviation in schizophrenia patient first-degree relatives (Fukushima et al 1988; Braff et al 1992; Iacono et al 1999; Hong et al 2012; Kam et al 2013; Chen et al 2014; Narayanan et al 2014; Qiu et al 2014). The only two endophenotypes that have not been linked to schizophrenia are our measures of affectively modulated startle (Iacono et al 2016).…”

Section: Introductionmentioning

confidence: 99%

Psychophysiological endophenotypes to characterize mechanisms of known schizophrenia genetic loci

et al. 2016

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Background Endophenotypes are laboratory-based measures hypothesized to lie in the causal chain between genes and clinical disorder, and to serve as a more powerful way to identify genes associated with the disorder. One promise of endophenotypes is that they may assist in elucidating the neurobehavioral mechanisms by which an associated genetic polymorphism affects disorder risk in complex traits. We evaluated this promise by testing the extent to which variants discovered to be associated with schizophrenia through large-scale meta-analysis show associations with psychophysiological endophenotypes. Method We genome-wide genotyped and imputed 4905 individuals. Of these, 1837 were whole-genome-sequenced at 11× depth. In a community-based sample, we conducted targeted tests of variants within schizophrenia-associated loci, as well as genome-wide polygenic tests of association, with 17 psychophysiological endophenotypes including acoustic startle response and affective startle modulation, antisaccade, multiple frequencies of resting electroencephalogram, electrodermal activity and P300 event-related potential. Results Using single variant tests and gene-based tests we found suggestive evidence for an association between contactin 4 (CNTN4) and antisaccade and P300. We were unable to find any other variant or gene within the 108 schizophrenia loci significantly associated with any of our 17 endophenotypes. Polygenic risk scores indexing genetic vulnerability to schizophrenia were not related to any of the psychophysiological endophenotypes after correction for multiple testing. Conclusions The results indicate significant difficulty in using psychophysiological endophenotypes to characterize the genetically influenced neurobehavioral mechanisms by which genome-wide association study-identified risk loci affect disorder risk.

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P300 waveform and dopamine transporter availability: a controlled EEG and SPECT study in medication-naive patients with schizophrenia and a meta-analysis

Cited by 15 publications

References 60 publications

Availability of dopamine transporters and auditory P300 abnormalities in adults with attention-deficit hyperactivity disorder: preliminary results

Availability of dopamine transporters and auditory P300 abnormalities in adults with attention-deficit hyperactivity disorder: preliminary results

Bilateral theta-burst magnetic stimulation influence on event-related brain potentials

Psychophysiological endophenotypes to characterize mechanisms of known schizophrenia genetic loci

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