P300 Latency and Age: A Quadratic Regression Explains Their Relationship from Age 5 to 85

Sangal, R. Bart; Jm, Sangal; Belisle, Cynthia

doi:10.1177/155005949802900105

Cited by 17 publications

(10 citation statements)

References 12 publications

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“…ERP responses to both paradigms are shown in Fig. 1 and appear to resemble those reported for children of Ž other ethnicities see Sangal et al, 1998;Sangal . and Sangal, 1996 .…”

Section: Descripti¨e Datasupporting

confidence: 60%

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Visual P3 findings in Mission Indian youth: relationship to family history of alcohol dependence and behavioral problems

Ehlers

Wall

Garcia‐Andrade

et al. 2001

Psychiatry Research

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Native Americans have some of the highest rates of alcohol abuse and dependence, yet risk factors for problem drinking remain relatively unknown. The amplitude of the P3 component of the event-related potential (ERP) has been suggested to be an index of 'vulnerability to alcoholism', especially when it is elicited by visual tasks in younger individuals. Visual P3 tasks, however, have not been previously investigated in Native American youth. One hundred and four Mission Indian youth between the ages of 7 and 13 years participated in the study. ERPs were collected using two visual target paradigms: a facial discrimination and an estimation of line orientation task. Analyses of covariance revealed that participants with a first degree family history of alcoholism had lower P3 component amplitudes in frontal leads to the facial discrimination task. Lower P3 amplitudes, in posterior areas, were found in the line discrimination task in children who scored above the 75th percentile in delinquent behaviors on the Achenbach Child Behavior Checklist. These findings are consistent with investigations in non-Indian populations demonstrating that the late positive component of the event related potential is sensitive to both familial history of alcohol dependence as well as personal history of externalizing behaviors.

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“…ERP responses to both paradigms are shown in Fig. 1 and appear to resemble those reported for children of Ž other ethnicities see Sangal et al, 1998;Sangal . and Sangal, 1996 .…”

Section: Descripti¨e Datasupporting

confidence: 60%

“…Ž . range 466 " 55 ms by Sangal et al 1998 . No significant associations were detected for P3 latency and FH or NAH.…”

Section: Descripti¨e Datamentioning

confidence: 98%

Visual P3 findings in Mission Indian youth: relationship to family history of alcohol dependence and behavioral problems

Ehlers

Wall

Garcia‐Andrade

et al. 2001

Psychiatry Research

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show abstract

“…Moreover, the latency and amplitude of the P300 decrease and increase respectively with age, until adolescence, reflecting maturation processes in the CNS (Martin et al 1988, Polich et al 1990, Sangal et al 1998). Effects of prenatal exposure to PCBs and dioxins on the P300 have been addressed in the Yu Cheng, Taiwan cohort (Chen and Hsu 1994), consisting of children born to mothers that were accidentally exposed to high levels of PCBs and polychlorinated dibenzofurans.…”

mentioning

confidence: 98%

“…In children, P300 abnormalities have been associated with several pathologies including cognitive dysfunction (Finley et al 1985, Kaneko et al 1996, attention-deficit disorders (Holcomb et al 1985, Satterfield et al 1990, and dyslexia (Taylor and Keenan 1990). Moreover, the latency and amplitude of the P300 decrease and increase respectively with age, until adolescence, reflecting maturation processes in the CNS (Martin et al 1988, Polich et al 1990, Sangal et al 1998). Effects of prenatal exposure to PCBs and dioxins on the P300 have been addressed in the Yu Cheng, Taiwan cohort (Chen and Hsu 1994), consisting of children born to mothers that were accidentally exposed to high levels of PCBs and polychlorinated dibenzofurans.…”

mentioning

confidence: 99%

Prenatal exposure to polychlorinated biphenyls and breastfeeding: opposing effects on auditory P300 latencies in 9‐year‐old Dutch children

Vreugdenhil¹,

Zanten²,

Brocaar³

et al. 2004

Develop Med Child Neuro

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Effects of perinatal exposure to polychlorinated biphenyls (PCBs) on auditory P300 latencies and amplitudes were evaluated in children from a Rotterdam cohort. From this cohort of healthy, term babies, the 26 lowest and 26 highest prenatally PCB-exposed children from the breastfed and the formula-fed groups (n=104) were invited for P300 assessment when they were 9 years of age. For P300 assessment an auditory simple odd-ball paradigm was used. In the 83 participating children, 60 assessments (32 males, 28 females) satisfied the measurement criteria and were included in the data analyses. After adjusting for confounding variables, children with high prenatal exposure were found to have longer P300 latencies than children with low prenatal exposure. Lactational exposure to PCBs through breastfeeding milk was not related to P300 latencies. P300 latencies were shorter in children breast-fed for at least 16 weeks than in children breastfed for 6 to 16 weeks and formula-fed children. P300 amplitudes were not related to perinatal PCB exposure nor breastfeeding. Results of this exploratory study suggest that prenatal exposure to environmental levels of PCBs and related compounds delays mechanisms in the central nervous system that evaluate and process relevant stimuli, whereas breastfeeding accelerates these mechanisms.

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“…Robust responders had significantly higher 31-electrode mean auditory P300 amplitude (11.7 vs 5.3 μv; t = 2.912; df = 11.2; p = 0.014). Seven of ten robust responders and one of seven nonresponders had a 31-electrode mean AA greater than 6.8 μV, which was the mean AA of our normal sample across age groups [32]. The Pearson chi-χ, using a cut-off of 6.8 μV, was 5.1, which gives a twotailed p = 0.024.…”

Section: Mph Responders Mph Nonrespondersmentioning

confidence: 99%

Attention-deficit/hyperactivity disorder: using P300 topography to choose optimal treatment

Sangal¹,

Sangal

2006

Expert Review of Neurotherapeutics

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Attention-deficit/hyperactivity disorder is the most prevalent behavioral disorder in children, and persists into adulthood. Stimulants (methylphenidate and amphetamines) with dopaminergic mechanisms are the most commonly used pharmacological treatment. Nonselective (desipramine and imipramine) and selective (atomoxetine) norepinephrine reuptake inhibitors can also be effective. What constitutes a sufficient response to treatment? Too often a partial response, leaving the patient symptomatic, is accepted. If response is defined more strictly, allowing for a return to normal, then the usually quoted 70% response rates to any given attention-deficit/hyperactivity disorder medicine drop to approximately 40%. With different medicines and not enough patients responding robustly to any given medicine, we can use medicines sequentially to find the medicine that produces a robust response. Alternatively, P300 topography can be used to select optimal treatment.

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P300 Latency and Age: A Quadratic Regression Explains Their Relationship from Age 5 to 85

Cited by 17 publications

References 12 publications

Visual P3 findings in Mission Indian youth: relationship to family history of alcohol dependence and behavioral problems

Visual P3 findings in Mission Indian youth: relationship to family history of alcohol dependence and behavioral problems

Prenatal exposure to polychlorinated biphenyls and breastfeeding: opposing effects on auditory P300 latencies in 9‐year‐old Dutch children

Attention-deficit/hyperactivity disorder: using P300 topography to choose optimal treatment

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